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Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. Zusätzlich bieten wir Ihnen ASH2L Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ASH2L Primary Antibody für ChIP, IHC (p) - ABIN153190
Rozenblatt-Rosen, Hughes, Nannepaga, Shanmugam, Copeland, Guszczynski, Resau, Meyerson: The parafibromin tumor suppressor protein is part of a human Paf1 complex. in Molecular and cellular biology 2005
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Human Polyclonal ASH2L Primary Antibody für ChIPSeq, ChIP - ABIN3434035
Cao, Chen, Cierpicki, Liu, Basrur, Lei, Dou: An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. in PLoS ONE 2010
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Human Polyclonal ASH2L Primary Antibody für IHC (p), IHC - ABIN153193
Stoller, Huang, Tan, Huang, Zhou, Yang, Gelb, Epstein: Ash2l interacts with Tbx1 and is required during early embryogenesis. in Experimental biology and medicine (Maywood, N.J.) 2010
Human Monoclonal ASH2L Primary Antibody für ICC, IF - ABIN2668901
Lüscher-Firzlaff, Gawlista, Vervoorts, Kapelle, Braunschweig, Walsemann, Rodgarkia-Schamberger, Schuchlautz, Dreschers, Kremmer, Lilischkis, Cerni, Wellmann, Lüscher: The human trithorax protein hASH2 functions as an oncoprotein. in Cancer research 2008
Data suggest an interplay between megakaryocytic leukemia 1 (MKL1 (zeige MKL1 Antikörper)) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (zeige TNF Antikörper)) induced proinflammatory transcription in macrophages.
the histone methyltransferase core enzyme ASH2L was bound at EGFR (zeige EGFR Antikörper) in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 (zeige EP300 Antikörper) was bound in samples with H3K27ac enrichment
Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.
ASH2L enhances ERalpha (zeige ESR1 Antikörper) expression as a coactivator of GATA3 (zeige GATA3 Antikörper) in breast cancers
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5 (zeige RBBP5 Antikörper)/Ash2L heterodimer.
Data indicate that MLL1 methylates Ash2L in the absence of histone H3 (zeige HIST3H3 Antikörper), but only when assembled within a complex with WDR5 (zeige WDR5 Antikörper) and RbBP5 (zeige RBBP5 Antikörper).
H2B dependent regulation of MLL (zeige MLL Antikörper) family histone methylatransferases depends on the N-terminal WH motif of ASH2L.
crystal structure of the C-terminal SPRY domain of human Ash2L
The structure shows that Ash2L contains an atypical PHD (zeige PDC Antikörper) finger that does not have histone tail-binding activity.
ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain.
We discuss the implications of these results to understand the role of ASH2L and Xist repeat E for histone modifications and escape gene regulation during random X-chromosome inactivation.
Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells
Tbx1 (zeige TBX1 Antikörper) and Ash2l have overlapping mRNA and protein expression patterns during development.
Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 (zeige FGFR3 Antikörper) is a novel direct target of these complexes.
Ap2delta associates with ASH2L and MLL2 (ALR (zeige MLL2 Antikörper)), forming a complex that methylates lysine 4 of histone H3 (zeige HIST3H3 Antikörper).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity).
, set1/Ash2 histone methyltransferase complex subunit ASH2