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ASAP1 encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. Zusätzlich bieten wir Ihnen ASAP1 Proteine (3) und ASAP1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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results, specifically, the absence of associations of polymorphisms of ASAP1 with tuberculosis (TB) risk, suggest that ASAP1 may not be a susceptibility gene for TB in Western Chinese Han and Tibetan population
results support the hypothesis that ASAP1 is a positive regulator of NM2A.
Rab11-FIP3 (zeige RAB11FIP3 Antikörper) coordinates the interactions of ASAP1 and Rab11a (zeige RAB11A Antikörper) with Rabin8 (zeige RAB3IP Antikörper).
The activation of NF-kappaB (zeige NFKB1 Antikörper) induced translocation of AMAP1 to cytoplasm from cell membrane and nucleus, which resulted in augmented interaction of AMAP1 and IKKbeta (zeige IKBKB Antikörper)
High ASAP1 expression, that was reduced after Mycobacterium tuberculosis infection, and rs10956514, are associated with the level of reduction of ASAP1 expression.
ASAP1 appears to contribute to the malignant mechanism of LSCC and may represent a significant prognostic marker for laryngeal squamous cell carcinoma patients.
results indicated that elevated expression of ASAP1 plays an important role in the progression and metastasis of ovarian cancer
Data show that co-overexpression of GEP100 (zeige IQSEC1 Antikörper) and AMAP1 (ASAP1) correlates with rapidity of the local recurrence.
found that AMAP1 had the ability to bind directly to PRKD2 (zeige PKD2 Antikörper) and hence to make a complex with the cytoplasmic tail of the beta1 subunit
Data suggest that GEP100 (zeige IQSEC1 Antikörper)-Arf6 (zeige ARF6 Antikörper)-AMAP1-cortactin (zeige CTTN Antikörper) pathway, activated by VEGFR2 (zeige KDR Antikörper), appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.
we demonstrate that Prox1 (zeige C16orf35 Antikörper) and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein (zeige DRG1 Antikörper) Arf4 (zeige ARF4 Antikörper) & the 2 G proteins of the Rab (zeige HRB Antikörper) family--Rab11 (zeige RAB11A Antikörper) & Rab8 (zeige RAB8A Antikörper)--linked by the Rab8 (zeige RAB8A Antikörper) guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) Rabin8 (zeige RAB3IP Antikörper).
ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS (zeige TLR4 Antikörper))-induced proinflammatory mediators production through down-regulating LPS (zeige TLR4 Antikörper) signaling
DEF-1 alters cell motility through the deactivation of ARF1 (zeige ARF1 Antikörper). In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
inhibited by tyrosine kinase (zeige TYRO3 Antikörper) Pyk2 (zeige PTK2B Antikörper), which also regulates Arf1 (zeige ARF1 Antikörper)
Overexpression of ASAP1 inhibits cell spreading and alters paxillin (zeige PXN Antikörper) localization to adhesions.
ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain (zeige ITSN1 Antikörper) and phosphorylation by Src (zeige SRC Antikörper).
ASAP3 (zeige ASAP3 Antikörper) functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
, development and differentiation enhancing factor 1
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like
, 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
, ADP-ribosylation factor-directed GTPase-activating protein 1
, ARF GTPase-activating protein 1
, PIP2-dependent ARF1 GAP
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
, centaurin, beta 4
, development and differentiation-enhancing factor 1
, differentiation-enhancing factor 1
, ArfGAP with SH3 domain, ankyrin repeat and PH domain1