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ASAP1 Antikörper (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1) pTyr782 Primary Antibody

ASAP1 Reaktivität: Maus IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (1 reference)
Produktnummer ABIN129669
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle ASAP1 Antikörper anzeigen
    ASAP1
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 777-787, pTyr782
    Reaktivität
    • 45
    • 36
    • 10
    • 6
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 53
    • 4
    • 1
    Kaninchen
    Klonalität
    • 55
    • 3
    Polyklonal
    Konjugat
    • 21
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ASAP1 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 29
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Kreuzreaktivität
    Human, Huhn, Schaf, Hund, Ratte (Rattus), Schimpanse
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 777-787 of mouse ASAP1 protein.
    Isotyp
    IgG
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, IF microscopy and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 130 kDa in size corresponding to phosphorylated ASAP1 protein by western blotting in the appropriate cell lysate or extract.  Less than 2.5% reactivity is observed against the non-phosphorylated form of the immunizing peptide.  This antibody is phospho specific for pY782 of ASAP1 protein.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.09 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Bender, Stritt, Nurden, van Eeuwijk, Zieger, Kentouche, Schulze, Morbach, Stegner, Heinze, Heinze, Dütting, Gupta, Witke, Falet, Fischer, Hartwig, Nieswandt: "Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect." in: Nature communications, Vol. 5, pp. 4746, (2015) (PubMed).

  • Target
    ASAP1
    Andere Bezeichnung
    ASAP1 (ASAP1 Produkte)
    Synonyme
    AV239055, DEF-1, Ddef1, PAP, mKIAA1249, s19, AMAP1, CENTB4, DDEF1, PAG2, ZG14P, ASAP1, ddef1, Asap1, si:ch211-160i2.3, ArfGAP with SH3 domain, ankyrin repeat and PH domain1, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1, toxic extracellular endopeptidase, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 L homeolog, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a, Asap1, ASAP1, asaP1, asap1, asap1.L, asap1a
    Hintergrund
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. ASAP1 (also known as AMAP1, 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein, PIP2-dependent ARF1 GAP,ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, Differentiation-enhancing factor 1, DEF-1) is an Arf-directed GTPase activating protein that is a substrate for the kinases Src and FAK and has been implicated in the regulation of membrane traffic, focal adhesions and invadopodia/podosomes.  Phosphorylation of ASAP1 at tyrosine 782 has been found to affect enzymatic and some biological activities, including the function of invadopodia. ASAP1 is expressed in many tissues but is most abundant in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. Multiple transcript variants have been reported for this protein.
    Synonyms: Development and differentiation enhancing factor 1 antibody, 130 kDa phosphatidylinositol 4 5 biphosphate dependent ARF1 GTPase activating protein antibody, ADP ribosylation factor directed GTPase activating protein 1 antibody, AMAP 1 antibody
    Gen-ID
    13196, 65301464
    UniProt
    Q9QWY8
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