anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antikörper

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Zusätzlich bieten wir Ihnen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Ziege Unkonjugiert ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Rind (Kuh) Ziege Unkonjugiert WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: APPL1 Antibody [ABIN252906] - APPL1 expression level after adenovirus transfection in rat aortic smooth muscle cells detected by ABIN252906. Western Blot: APPL Antibody [ABIN2529061] - Staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL adenovirus for 48hrs using ABIN2529061 at 0.5ug/ml. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
801,43 €
Details
Maus Kaninchen Unkonjugiert ICC, IF, IHC (p), IP, WB 50 μL Anmelden zum Anzeigen 3 bis 4 Tage
437,80 €
Details
Human Kaninchen Unkonjugiert WB Western Blot: APPL Antibody [NBP2-15433] - Sample (50 ug of whole cell lysate) A: Mouse brain 7. 5% SDS PAGE; antibody diluted at 1:1000. Western Blot: APPL Antibody [NBP2-15433] - Sample (30 ug of whole cell lysate) A: IMR32 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: APPL Antibody [NBP2-15434] - Paraffin-embedded AZ521 xenograft, using antibody at 1:100 dilution. Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Rind (Kuh) Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
722,86 €
Details
Human Ziege Unkonjugiert ELISA, WB Antibody (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details

APPL1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)
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Rat (Rattus)
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Am meisten referenzierte anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antikörper

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody für ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal APPL1 Primary Antibody für ELISA, WB - ABIN252906 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006 (PubMed)

Weitere Antikörper gegen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Interaktionspartner

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. APPL1 positively mediated leptin (zeige LEP Antikörper) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (zeige RAB5A Antikörper) overactivation through beta-cleaved carboxy-terminal fragment of APP (zeige APP Antikörper)-APPL1 interactions constitutes a novel APP (zeige APP Antikörper)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (zeige RAB5A Antikörper)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (zeige TSC2 Antikörper)

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (zeige TLR3 Antikörper)/4-dependent TBK1 (zeige TBK1 Antikörper) and IKKepsilon (zeige IKBKE Antikörper) activation in macrophages.

  10. ATM (zeige ATM Antikörper) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (zeige TLR4 Antikörper)-induced signaling, transcription, and cytokine secretion.

  2. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF Antikörper)-induced Akt (zeige AKT1 Antikörper) activation, migration, and invasion.

  3. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (zeige PRKAA1 Antikörper) signaling.

  4. A role for APPL1 in TLR3 (zeige TLR3 Antikörper)/4-dependent TBK1 (zeige TBK1 Antikörper) and IKKepsilon (zeige IKBKE Antikörper) activation in macrophages.

  5. APPL1 sensitizes insulin (zeige INS Antikörper) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (zeige INS Antikörper) signaling and crosstalk between the insulin (zeige INS Antikörper) and adiponectin (zeige ADIPOQ Antikörper) pathways.

  6. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  7. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (zeige INS Antikörper) sensitivity.

  8. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (zeige INS Antikörper) resistance and improves adipoR1 (zeige ADIPOR1 Antikörper)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  9. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (zeige AKT1 Antikörper) cascade in neurons.

  10. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (zeige INS Antikörper) resistance to beta-cell dysfunction in type 2 diabetes.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antigen-Profil

Protein Überblick

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Genbezeichner und Symbole assoziert mit APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) Antikörper
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) Antikörper
  • 2900057D21Rik Antikörper
  • 7330406P05Rik Antikörper
  • AI585782 Antikörper
  • APPL Antikörper
  • AW209077 Antikörper
  • BB022931 Antikörper
  • C88264 Antikörper
  • DIP13 Antikörper
  • DIP13alpha Antikörper
  • RGD1309388 Antikörper

Bezeichner auf Proteinebene für APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPEZIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
Ausgewählte Anbieter für anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antikörper
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