anti-ATP Citrate Lyase (ACLY) Antikörper

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Zusätzlich bieten wir Ihnen ACLY Kits (22) und ACLY Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
ACLY 24159 P16638
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Top anti-ACLY Antikörper auf antikoerper-online.de

Showing 10 out of 125 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-ACLY Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>ACHN cell lysate WB Suggested Anti-ACLY <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: ACHN cell lysate <br /> ACLY is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-ACLY Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>ACHN cell lysate WB Suggested Anti-ACLY <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: ACHN cell lysate <br /> ACLY is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using ACLY mouse mAb (green) and negative control (purple) . 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$430.10
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COS7 cells, treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Ab-454) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB   100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert ELISA, IF, WB Western Blot (WB) analysis of specific cells using ATP-citrate synthase Polyclonal Antibody. 100 μL Anmelden zum Anzeigen 16 Days
$175.80
Details
Human Maus Unkonjugiert IF, IHC (p), WB Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details
Human Maus Unkonjugiert FACS, ICC, WB   100 μL Anmelden zum Anzeigen 12 bis 14 Tage
$200.00
Details
Human Kaninchen Unkonjugiert ICC, IF, WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details

ACLY Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-ACLY Antikörper

  1. Human Monoclonal ACLY Primary Antibody für ICC, FACS - ABIN1098143 : Chu, Lin, Hendel, Kulpa, Brownsey, Johnson: ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal ACLY Primary Antibody für IHC, WB - ABIN2775558 : Infantino, Iacobazzi, Palmieri, Menga: ATP-citrate lyase is essential for macrophage inflammatory response. in Biochemical and biophysical research communications 2013 (PubMed)

  3. Cow (Bovine) Polyclonal ACLY Primary Antibody für WB - ABIN2773810 : Convertini, Menga, Andria, Scala, Santarsiero, Castiglione Morelli, Iacobazzi, Infantino: The contribution of the citrate pathway to oxidative stress in Down syndrome. in Immunology 2016 (PubMed)

Weitere Antikörper gegen ACLY Interaktionspartner

Human ATP Citrate Lyase (ACLY) Interaktionspartner

  1. ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

  2. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.

  3. CUL3 (zeige CUL3 Antikörper) interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  4. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  5. Results show that ACLY is a key phosphoprotein effector of IL-2 (zeige IL2 Antikörper)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (zeige IL2 Antikörper)-driven activation of AKT (zeige AKT1 Antikörper), and depletion or inactivation of ACLY compromises IL-2 (zeige IL2 Antikörper)-promoted T-cell growth.

  6. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (zeige PLIN2 Antikörper)), a marker of lipid droplet formation, associated with favorable prognosis

  7. ACC1 (zeige ACACA Antikörper) and ACLY regulate the levels of ETV4 (zeige ETV4 Antikörper) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (zeige ACACA Antikörper)/ACLY-alpha-ketoglutarate-ETV4 (zeige ETV4 Antikörper) axis is a novel means by which metabolic states regulate transcriptional output

  8. ACL activity is associated with increased ATP. Activation of this IGF1 (zeige IGF1 Antikörper)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  9. These results suggest that the combined expression of GLUT1 (zeige SLC2A1 Antikörper) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  10. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

Mouse (Murine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. ACL (zeige APOC4 Antikörper) plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  2. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (zeige LDLR Antikörper) knockout mouse model of metabolic dysregulation.

  3. IL-4 (zeige IL4 Antikörper) signaling co-opts the Akt (zeige AKT1 Antikörper)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (zeige LPCAT1 Antikörper) synthesis, leading to increased histone acetylation and macrophage gene induction.

  4. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (zeige TLR4 Antikörper) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  5. Results suggest a role for DNA methyltransferase 1 (DNMT1 (zeige DNMT1 Antikörper)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (zeige MLXIP Antikörper)-148a-dependent mechanism for regulating DNMT1 (zeige DNMT1 Antikörper) during adipogenesis.

  6. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (zeige PC Antikörper), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  7. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (zeige APOC4 Antikörper) in lipid metabolism.

  8. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  9. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  10. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (zeige TFAP2A Antikörper).

Cow (Bovine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY Antigen-Profil

Protein Überblick

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit ACLY

  • ATP citrate lyase (ACLY) Antikörper
  • ATP citrate lyase S homeolog (acly.S) Antikörper
  • ATP-citrate synthase (LOC587157) Antikörper
  • ATP citrate lyase (acly) Antikörper
  • ATP citrate lyase (ATPCL) Antikörper
  • ATP-citrate synthase (LOC5564509) Antikörper
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) Antikörper
  • ATP-citrate synthase (Bm1_26245) Antikörper
  • atp-citrate synthase (ACL) Antikörper
  • ATP citrate lyase (Acly) Antikörper
  • ATP citrate lyase a (aclya) Antikörper
  • A730098H14Rik Antikörper
  • ACL Antikörper
  • acly Antikörper
  • anon-WO0140519.179 Antikörper
  • ATPCL Antikörper
  • AW538652 Antikörper
  • BcDNA:LD21334 Antikörper
  • cb722 Antikörper
  • CG8322 Antikörper
  • Clatp Antikörper
  • dATPCL Antikörper
  • DDBDRAFT_0205389 Antikörper
  • DDBDRAFT_0235360 Antikörper
  • DDB_0205389 Antikörper
  • DDB_0235360 Antikörper
  • DmATPCL Antikörper
  • Dmel\\CG8322 Antikörper
  • l(2)01466 Antikörper
  • l(2)k09217 Antikörper
  • n(2)k09217 Antikörper
  • zgc:92008 Antikörper

Bezeichner auf Proteinebene für ACLY

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

GENE ID SPEZIES
100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
Ausgewählte Anbieter für anti-ACLY (ACLY) Antikörper
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