anti-AF4/FMR2 Family, Member 4 (AFF4) Antikörper

The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia. Zusätzlich bieten wir Ihnen AFF4 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
AFF4 27125 Q9UHB7
AFF4 93736 Q9ESC8
AFF4 303132  
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Top anti-AFF4 Antikörper auf antikoerper-online.de

Showing 10 out of 68 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Aff4 Antibody Titration: 1.0 ug/ml Positive Control: Rat Small Intestine 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of AF5q31 Antibody (N-term) (ABIN653641) in HL-60 cell line lysates (35 µg/lane). AF5q31 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of AF5q31 Antibody (N-term) in HL-60 cell line lysates (35µg/lane). AF5q31 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Maus Unkonjugiert WB Western Blot analysis of AFF4 expression in transfected 293T cell line by AFF4 monoclonal antibody (M01), clone 2E12. Lane 1: AFF4 transfected lysate( 40.2 KDa). Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to AFF4 on formalin-fixed paraffin-embedded human endometrium (antibody concentration 1 µg/mL). 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Details
Human Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: AFF4 Antibody [NBP1-89220] - Staining of human cell line U-2 OS shows positivity in nucleus & mitochondria. Immunohistochemistry-Paraffin: AFF4 Antibody [NBP1-89220] - Staining of human hippocampus shows strong nuclear positivity in glial cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Meerschweinchen Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extract of various cells, using AFF4 antibody. 100 μL Anmelden zum Anzeigen 12 Days
392,86 €
Details
Human Kaninchen Unkonjugiert IP 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert IP 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details

AFF4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-AFF4 Antikörper

  1. Human Polyclonal AFF4 Primary Antibody für ICC, IF - ABIN4278570 : Stasevich, Hayashi-Takanaka, Sato, Maehara, Ohkawa, Sakata-Sogawa, Tokunaga, Nagase, Nozaki, McNally, Kimura: Regulation of RNA polymerase II activation by histone acetylation in single living cells. in Nature 2014 (PubMed)

Weitere Antikörper gegen AFF4 Interaktionspartner

Human AF4/FMR2 Family, Member 4 (AFF4) Interaktionspartner

  1. AFF4 is positioned to make unexpected direct contacts with HIV Tat (zeige TAT Antikörper), and Tat (zeige TAT Antikörper) enhances P-TEFb (zeige CCNT1 Antikörper)/CCNT1 (zeige CCNT1 Antikörper) affinity for AFF4.

  2. missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (zeige NIPBL Antikörper)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)

  3. HIV-1 Tat (zeige TAT Antikörper) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

  4. overexpression of AFF2 (zeige AFF2 Antikörper)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.

  5. Through the bridging functions of Tat (zeige TAT Antikörper) and AFF4, P-TEFb (zeige CCNT1 Antikörper) and ELL2 (zeige ELL2 Antikörper) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.

  6. AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.

  7. MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (zeige TAT Antikörper)-transactivation.

  8. Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]

Mouse (Murine) AF4/FMR2 Family, Member 4 (AFF4) Interaktionspartner

  1. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (zeige MLLT1 Antikörper)/3 and AFF proteins that is critically important for MLL (zeige MLL Antikörper)-mediated transformation of HPCs

  2. AFF4 may therefore help to maintain activation of AMPK (zeige PRKAA1 Antikörper) downstream signaling under conditions of prolonged stimulation with ghrelin (zeige GHRL Antikörper), such as during fasting.

  3. AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.

  4. Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II

  5. In the absence of Runx1 (zeige RUNX1 Antikörper) on the silencer, P-TEFb (zeige CCNT1 Antikörper) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (zeige CD4 Antikörper) gene

AFF4 Antigen-Profil

Protein Überblick

The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).

Genbezeichner und Symbole assoziert mit AFF4

  • AF4/FMR2 family, member 4 (aff4) Antikörper
  • AF4/FMR2 family, member 4 (AFF4) Antikörper
  • AF4/FMR2 family, member 4 (Aff4) Antikörper
  • AF5Q31 Antikörper
  • AFF4 Antikörper
  • Alf4 Antikörper
  • Laf4l Antikörper
  • MCEF Antikörper
  • RA_m002_jsmFBA6Br Antikörper

Bezeichner auf Proteinebene für AFF4

AF4/FMR2 family, member 4 , ALL1 fused gene from 5q31 , AF4/FMR2 family member 4-like , AF4/FMR2 family member 4 , ALL1-fused gene from chromosome 5q31 protein , major CDK9 elongation factor-associated protein

GENE ID SPEZIES
446225 Xenopus laevis
462058 Pan troglodytes
100137227 Papio anubis
100328920 Oryctolagus cuniculus
100403628 Callithrix jacchus
556421 Danio rerio
100548612 Meleagris gallopavo
27125 Homo sapiens
93736 Mus musculus
416337 Gallus gallus
474678 Canis lupus familiaris
541306 Bos taurus
303132 Rattus norvegicus
Ausgewählte Anbieter für anti-AFF4 (AFF4) Antikörper
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