ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteine (ADAMTS4)

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Zusätzlich bieten wir Ihnen ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antikörper (167) und ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (42) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
Ratte ADAMTS4 ADAMTS4 66015 Q9ESP7
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Top ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteine auf antikoerper-online.de

Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Human His tag 5 μg Anmelden zum Anzeigen 6 bis 7 Tage
$271.43
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$205.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$838.75
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ADAMTS4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, ,

Weitere Proteine zu ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Interaktionspartner

  1. the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues

  2. Results show that ADAMTS15 (zeige ADAMTS15 Proteine) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

  3. aggrecan (zeige ACAN Proteine) and brevican (zeige BCAN Proteine) proteolysis is compensated in Adamts4-/- or Adamts5 (zeige ADAMTS5 Proteine)-/- mice by ADAMTS (zeige ADAMTS1 Proteine) proteoglycanase (zeige MMP3 Proteine) family members but a threshold of versican (zeige Vcan Proteine) proteolysis is sensitive to the loss of a single ADAMTS (zeige ADAMTS1 Proteine) proteoglycanase (zeige MMP3 Proteine) during spinal cord injury

  4. ADAMTS4 has roles in melanoma growth and angiogenesis in mice

  5. The serine protease (zeige F2 Proteine) tissue plasminogen activator (tPA (zeige PLAT Proteine)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (zeige ADAMTS5 Proteine), were identified as Reelin (zeige RELN Proteine) cleaving enzymes.

  6. ADAMTS-4 cleaves Reelin (zeige RELN Proteine) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (zeige LSP1 Proteine) cleaves the N-t site only, while p75 (zeige NGFR Proteine) cleaves both sites.

  7. Data demonstrate that Adamts1 (zeige ADAMTS1 Proteine) and Adamts4 play redundant and essential roles in perinatal kidney development.

  8. Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.

  9. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue

  10. ADAMTS1 (zeige ADAMTS1 Proteine), ADAMTS4, and ADAMTS5 (zeige ADAMTS5 Proteine) are expressed in patterns that relate to the expression pattern of versican (zeige Vcan Proteine) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Interaktionspartner

  1. Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (zeige FBLN2 Proteine) is a better substrate for ADAMTS-5 (zeige ADAMTS5 Proteine) than it is for ADAMTS-4. Fibulin-2 (zeige FBLN2 Proteine) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.

  2. ADAMTS4 and ADAMTS15 (zeige ADAMTS15 Proteine) were upregulated in symptomatic uterine leiomyomas.

  3. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.

  4. Single Nucleotide Variants of Candidate Genes in Aggrecan (zeige ACAN Proteine) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  5. Results show that ADAMTS4 mRNA is the target of mir (zeige MLXIP Proteine)-1268a and its expression might be modified by MIR (zeige MLXIP Proteine)-1268a rs28599926 polymorphism in hepatocellular carcinoma.

  6. we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 (zeige ADAMTS5 Proteine) genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 (zeige ADAMTS5 Proteine) genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (zeige ADAMTS5 Proteine) (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.

  7. ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing

  8. ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .

  9. in degenerative intervertebral discs, IL1b (zeige IL1B Proteine) upregulates NFkB, MMP13 (zeige MMP13 Proteine) and ADAMTS4

  10. progesterone acts via the progesterone receptor (zeige PGR Proteine) to modulate ADAMTS 1 (zeige ADAMTS1 Proteine) and 4 levels in ovarian cancer cell lines.

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Interaktionspartner

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha (zeige TNF Proteine)-dependent aggrecan (zeige ACAN Proteine) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 (zeige ADAMTS5 Proteine) are inhibited by alpha2-macroglobulin (zeige A2M Proteine)

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (zeige ADAMTS5 Proteine)

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Protein Überblick

Protein Überblick

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Genbezeichner und Symbole assoziert mit ADAMTS4

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4)
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4)
  • ADAMTS like 4 (ADAMTSL4)
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4)
  • 3830423K05 Protein
  • ADAM-TS4 Protein
  • ADAMTS-2 Protein
  • ADAMTS-4 Protein
  • ADAMTS4 Protein
  • ADMP-1 Protein
  • mKIAA0688 Protein

Bezeichner auf Proteinebene für ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , aggrecanase-1 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , ADAM metallopeptidase with thrombospondin type 1 motif, 4 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , disintegrin and metalloproteinase with thrombospondin motifs 2 , a disintegrin and metalloproteinase with thrombospondin motifs 4

GENE ID SPEZIES
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
457453 Pan troglodytes
488651 Canis lupus familiaris
719927 Macaca mulatta
100033914 Equus caballus
100409334 Callithrix jacchus
100008765 Oryctolagus cuniculus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
100514576 Sus scrofa
100712995 Cavia porcellus
101106565 Ovis aries
100461178 Pongo abelii
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