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ABI3 encodes a member of an adaptor protein family. Zusätzlich bieten wir Ihnen ABI3 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal ABI3 Primary Antibody für WB - ABIN1881513
Ichigotani, Yokozaki, Fukuda, Hamaguchi, Matsuda: Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. in Cancer research 2002
Show all 2 Pubmed References
Result links ABI3 to the pathogenesis and progression of some cancers and suggests that ABI3 or its pathway might have interest as therapeutic target.
Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
NESH (Abi-3), like Abi-1 (zeige ABI1 Antikörper) and Abi-2 (zeige ABI2 Antikörper), is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (zeige ABL1 Antikörper).
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1 (zeige ABI1 Antikörper), which led to the formation of a NESH/Abi-3-based WAVE2 (zeige WASF2 Antikörper) complex.
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.
ABI gene family member 3
, ABI gene family, member 3
, new molecule including SH3
, NESH protein