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Human Polyclonal SPHK2 Primary Antibody für IHC (p), WB - ABIN391348
Liu, Sugiura, Nava, Edsall, Kono, Poulton, Milstien, Kohama, Spiegel: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. in The Journal of biological chemistry 2000
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Human Polyclonal SPHK2 Primary Antibody für IF (p), IHC (p) - ABIN748613
Zhang, Li, Yuan, Zhao: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway. in Experimental and molecular pathology 2016
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Human Polyclonal SPHK2 Primary Antibody für IHC (p), WB - ABIN391349
Shutler, Glassco, Kang, Korneluk, Mueller: Genomic structure of the human D-site binding protein (DBP) gene. in Genomics 1996
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Sk1 (zeige SPHK1 Antikörper) and Sk2 (zeige KCNN2 Antikörper) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
Data show that inhibition of sphingosine kinase-2 by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2 (zeige RRM2 Antikörper)) and c-MYC (zeige MYC Antikörper) protein (Myc (zeige MYC Antikörper)) in all three cell lines.
miR (zeige MLXIP Antikörper)-613 functions as a tumor suppressor in papillary thyroid carcinoma and its suppressive effect is mediated by repressing SphK2 expression
results were consistent across all of the four serotypes of DENV infection, which supports the pro-apoptotic role of SPHK2 in DENV-infected liver cells
sphingosine kinase-2 plays an important role in kidney fibrogenesis by modulating transforming growth factor-beta signaling
SphKs/Sphingosine-1-phosphate signaling is critical for the growth and survival of estrogen receptor (zeige ESR1 Antikörper) positive MCF-7 human breast cancer cells.
The analysis suggests that the catalytic function and regulation of SPHK1 (zeige SPHK1 Antikörper) and SPHK2 might be dependent on their conformational mobility. (Review)
In this study, we describe the findings that overexpression of SphK2 promotes chemoresistance in non-small cell lung cancer (NSCLC) cells. Inhibition of SphK2 might be considered as a strategy in NSCLC treatment with gefitinib
the pathogenesis of CRC (zeige CALR Antikörper) maybe mediated by SphK2, and SphK2 could represent a selective target for the molecularly targeted treatments of CRC (zeige CALR Antikörper)
data suggest that in vitro inhibition of SK-2 (zeige KCNN2 Antikörper), can compromise the integrity of the EC monolayer
ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (zeige DEGS1 Antikörper).
Taken together, we conclude that antamiR-613 protects neuronal cells from OGDR probably via inducing SphK2 expression.
data suggest that in vitro inhibition of SK-2 (zeige PAPSS2 Antikörper), can compromise the integrity of the EC monolayer
Results show that Sphk2/S1P (zeige S1PR1 Antikörper) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease
Demonstrate that Sphk2 is the major Sphk (zeige SPHK1 Antikörper) isoform responsible for the generation of S1P (zeige S1PR1 Antikörper) in platelets and plays a pivotal intrinsic role in the control of platelet activation.
transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (zeige ATF4 Antikörper) and improves perturbed hepatic glucose and fatty acid metabolism
These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (zeige BECN1 Antikörper)/Bcl-2 (zeige BCL2 Antikörper) interaction.
SK1 (zeige SPHK1 Antikörper) and SK2 (zeige PAPSS2 Antikörper) down-regulation reduces the motility of satellite cells.
attenuation of Sphk1 (zeige SPHK1 Antikörper), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.
Sphk2 provides the source of intracellular S1P (zeige S1PR1 Antikörper) that controls thrombopoiesis, which is associated with Src (zeige SRC Antikörper) family kinases expression and activity in megakaryocytes.
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, sphingosine kinase 2
, sphingosine kinase
, sphingosine kinase II
, sphingosine kinase 2-like
, sphingosine kinase type 2
, SK 2
, SPK 2
, Spk2, Sk2