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Human Monoclonal PCNA Primary Antibody für ICC, IHC (fro) - ABIN3044483
Tian, Wei, Li, Wang, Zhang, Xie: Pathway of programmed cell death and oxidative stress induced by ?-hydroxybutyrate in dairy cow abomasum smooth muscle cells and in mouse gastric smooth muscle. in PLoS ONE 2014
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Chicken Monoclonal PCNA Primary Antibody für ChIP, ELISA - ABIN152935
Waseem, Lane: Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. in Journal of cell science 1990
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Human Polyclonal PCNA Primary Antibody für IHC - ABIN966812
Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. in British journal of cancer 2009
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Human Polyclonal PCNA Primary Antibody für IHC - ABIN966811
Niwa, Miwa, Kuzuya, Iwasaki, Haneda, Ueki, Katayama, Hiramitsu, Goto, Nagasaka, Watarai, Uchida, Nakao, Kobayashi: Stimulation index for PCNA mRNA in peripheral blood as immune function monitoring after renal transplantation. in Transplantation 2009
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Hamster Monoclonal PCNA Primary Antibody für IF, IP - ABIN334654
Rottach, Kremmer, Nowak, Boisguerin, Volkmer, Cardoso, Leonhardt, Rothbauer: Generation and characterization of a rat monoclonal antibody specific for PCNA. in Hybridoma (2005) 2008
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Human Monoclonal PCNA Primary Antibody für ICS - ABIN2689878
Schlatt, Weinbauer: Immunohistochemical localization of proliferating cell nuclear antigen as a tool to study cell proliferation in rodent and primate testes. in International journal of andrology 1995
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Human Polyclonal PCNA Primary Antibody für IF (p), IHC (p) - ABIN672756
Song, Yan, An, Hao, Guo, Zhang, Li, Li, Sun: Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in rats. in Brain research 2013
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Human Polyclonal PCNA Primary Antibody für ICC, FACS - ABIN151904
Ramos-Nino, Blumen, Sabo-Attwood, Pass, Carbone, Testa, Altomare, Mossman: HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. in American journal of respiratory cell and molecular biology 2008
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Human Monoclonal PCNA Primary Antibody für IF (p), IHC (p) - ABIN723006
Hao, Zhang, Cheng, Li, Sun, Zhang, Guo, Li: Imidapril inhibits right ventricular remodeling induced by low ambient temperature in broiler chickens. in Poultry science 2013
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Human Polyclonal PCNA Primary Antibody für IF, IHC (p) - ABIN389344
Wang, Zheng, Luo, Fan, Chen, Zhang, Hui: KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. in Journal of cellular biochemistry 2009
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Results show that regulation of e2f1 (zeige E2F1 Antikörper) and PCNA by DREF (zeige ZBED1 Antikörper) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
E2F (zeige E2F2 Antikörper) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (zeige POLD1 Antikörper). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]
this study shows that cytoplasmic PCNA connects glycolysis and cell survival in acute myeloid leukemia (zeige BCL11A Antikörper)
The results revealed that PCNA is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA colocalize in the cytoplasm, suggesting that they may interact in this compartment.
PCNA and E-cadherin (zeige CDH1 Antikörper) may have roles in prognosis of patients with gastric cancer
PCNA and MutLalpha interact specifically but weakly in solution to form a complex of approximately 1:1 stoichiometry that depends on PCNA interaction with the C-terminal endonuclease domain of the MutLalpha PMS2 (zeige PMS2 Antikörper) subunit.
FAN1 (zeige FSCN1 Antikörper) interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 (zeige BRCA2 Antikörper)
Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA and eIF4E (zeige EIF4E Antikörper). Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 (zeige TP53 Antikörper) and p21 (zeige CDKN1A Antikörper), and the reduction of PCNA and eIF4E (zeige EIF4E Antikörper) expression levels.
The here presented evidence that the PCNA inner surface is highly regulated to control DNA damage resistance represents a new concept that offers new opportunities to develop tools to manipulate the DNA damage response in cancer treatment. [review]
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R (zeige IGF1R Antikörper) interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 (zeige RAD18 Antikörper) and SHPRH (zeige SHPRH Antikörper). (IGF1R (zeige IGF1R Antikörper) = insulin-like growth factor 1 receptor (zeige IGF1R Antikörper); PCNA = proliferating cell nuclear antigen; RAD18 (zeige RAD18 Antikörper) = E3 ubiquitin-protein ligase RAD18 (zeige RAD18 Antikörper); SHPRH (zeige SHPRH Antikörper) = E3 ubiquitin-protein ligase SHPRH (zeige SHPRH Antikörper))
Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 (zeige UHRF2 Antikörper) that contains a PIP (zeige PIP Antikörper) box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 (zeige UHRF2 Antikörper) by PCNA via PIP (zeige PIP Antikörper)-box.
The complex between p15PAF (zeige PAF Antikörper) and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling.
e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 (zeige Kdm6b Antikörper) to decrease H3K27me3, which also showed to suppress the MEK (zeige MDK Antikörper)-ERK (zeige EPHB2 Antikörper) pathway. Furthermore, Co-IP analysis demonstrated that TET1 (zeige TET1 Antikörper) interact with PCNA and HDAC1 (zeige HDAC1 Antikörper) by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA- and ATM (zeige ATM Antikörper)/ATR (zeige ATR Antikörper)-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.
REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (zeige RAD18 Antikörper).
PCNA was mainly localized in decidual-stromal cells.
Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (zeige ICAM1 Antikörper) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.
Data suggest Usp1 (ubiquitin specific peptidase 1 (zeige USP1 Antikörper)) down-regulation by autocleavage is critical for Usp1 (zeige USP1 Antikörper) to exert role in DNA interstrand crosslink repair; Usp1 (zeige USP1 Antikörper) role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2 (zeige FANCD2 Antikörper)).
The aberrant DNA replication mediated by the PCNA-DNA pol-beta (zeige POLB Antikörper) complex induces p53 (zeige TP53 Antikörper)-dependent neuronal cell death
Demonstrate that miR (zeige MLXIP Antikörper)-376a regulates primordial follicle assembly by modulating the expression of Pcna.
while interaction with PCNA was important for targeting p21 (zeige D4S234E Antikörper) to the CRL4Cdt2 ligase re-localized to MVM replication centers
Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.
The expression of telomerase activity and TERT (zeige TERT Antikörper) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Antikörper), wee1 (zeige WEE1 Antikörper), p21 (zeige CDKN1A Antikörper), PCNA and cdk2 (zeige CDK2 Antikörper), but only weakly influences cyclin B1 (zeige CCNB1 Antikörper), cyclin B2 (zeige CCNB2 Antikörper) and cyclin E1 (zeige CCNE1 Antikörper) expression.
There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish
residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates
CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.
PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.
Immunodepletion of Swift PAX-interacting protein 1 (zeige PAXIP1 Antikörper) from Xenopus extracts prevented efficient PCNA ubiquitination
PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
, proliferating cell nuclear antigen
, proliferating-cell nuclear antigen
, DNA polymerase delta auxiliary protein
, proliferating cell nuclear antigen subtype1
, proliferating cell nuclear antigen subtype2
, proliferating cell nuclear antigen subtype3
, proliferative cell nuclear antigen