PCNA Antikörper (C-Term)

Produktnummer ABIN2792157

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PCNA in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio) und Rind (Kuh).Es wurde in 1 Publikation zitiert.

Kurzübersicht für PCNA Antikörper (C-Term) (ABIN2792157)

Target: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCNA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PCNA Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PCNA Antibody - C-terminal region

Sequenz: LNFFTKATPL SSTVTLSMSA DVPLVVEYKI ADMGHLKYYL APKIEDEEGS

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against PCNA. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCNA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PCNA Antikörper (ABIN2792157)

Liu, Meng, Li, Zhou, Zeng, He, Mrsny, Liu, Hu, Hu, Li: "Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure." in: Cytotherapy, Vol. 16, Issue 9, pp. 1207-19, (2014) (PubMed).

Details zu PCNA

Target: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Andere Bezeichnung: PCNA

Hintergrund:

Background Information: PCNA is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Gene Name: Proliferating cell nuclear antigen

Alternative Symbols: ATLD2

Protein Name: Proliferating cell nuclear antigen

Molekulargewicht: 29kDa

Gen-ID: 5111

NCBI Accession: NP_002583

UniProt: P12004

Pathways: Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie