The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008].
CD3E
Spezies: Cynomolgus
Wirt: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Aktuelle Publikationen für unsere CD3 epsilon Proteine
Knowling, Clark, Sjuts, Abdiche: "Direct Comparison of Label-Free Biosensor Binding Kinetics Obtained on the Biacore 8K and the Carterra LSA." in: SLAS discovery : advancing life sciences R & D, Vol. 25, Issue 9, pp. 977-984, (2020) (PubMed).
Zielonka, Empting, Könning, Grzeschik, Krah, Becker, Dickgießer, Kolmar: "The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope." in: Marine biotechnology (New York, N.Y.), Vol. 17, Issue 4, pp. 386-92, (2015) (PubMed).