CD3 epsilon (CD3E) (AA 23-126) (Active) protein (His tag,Fc Tag)

Produktnummer ABIN2180738

Produktdetails

Target: CD3 epsilon (CD3E)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 23-126

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD3 epsilon Protein ist gelabelt mit His tag,Fc Tag.

Sequenz: AA 23-126

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 39.2 kDa. The protein migrates as 44-54 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Antigendetails

Target: CD3 epsilon (CD3E)

Andere Bezeichnung: CD3 epsilon (CD3E Produkte)

Synonyme: cd3e, CD3E, t3e, tcre, AI504783, CD3, CD3epsilon, T3e, T3E, TCRE, CD3e molecule, CD3 antigen, epsilon polypeptide, cd3e, CD3E, Cd3e

Hintergrund: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Molekulargewicht: 39.2 kDa

NCBI Accession: NP_000724

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway