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SARS-CoV-2 Spike S1 Proteine

(SARS-CoV-2 Spike S1)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

104 Treffer

Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. SDS, ELISA
Pubmed 1 reference
Produktnummer ABIN6952630
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
Pubmed 3 Referenzen
Produktnummer ABIN6952457
 
Spezies: SARS Coronavirus (SARS-CoV) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7275550
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274409
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274872
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274392
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274396
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Produktnummer ABIN7274390
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % by SDS-PAGE. SDS, Func Active
Produktnummer ABIN6952742
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 90 % by SDS-PAGE. SDS, Func Active
Produktnummer ABIN6952732
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. WB
Produktnummer ABIN6961173
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. WB
Produktnummer ABIN6961172
 
Spezies: SARS Coronavirus (SARS-CoV) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7275551
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274410
 
Spezies: SARS Coronavirus (SARS-CoV) Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7275553
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant >95 % by SDS-PAGE,> 95 % by HPLC SDS, Func Active
Produktnummer ABIN6952735
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Produktnummer ABIN6992377
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Produktnummer ABIN6992361
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6992403
 
Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. WB
Produktnummer ABIN6961171
 
  • Typ Protein
    • Protein
  • Anwendung
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Functional Studies (Func)
    • Lateral Flow (LF)
    • Control (Ct)
    • Enzyme Immunoassay (EIA)
    • Immunogen (Imm)
    • Positive Control (PC)
  • Reaktivität
    • SARS Coronavirus-2 (SARS-CoV-2)
    • SARS Coronavirus (SARS-CoV)
    • SARS CoV-2 Beta
    • SARS CoV-2 Omicron
    • SARS CoV-2 Delta
    • SARS CoV-2 Alpha
    • SARS CoV-2 Gamma
    • SARS CoV-2 Kappa
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Preservative free only
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Insect Cells
    • Escherichia coli (E. coli)
    • CHO Cells
    • Human Cells
    • Tobacco (Nicotiana benthamiana)
  • Bindungsspezifität
    • AA 319-541
    • RBD
    • B.1.351 - beta
    • N-Term
    • AA 1-674
    • B.1.1.529 - Omicron
    • B.1.617.2 - delta
    • N501Y
    • BA.4 - Omicron
    • BA.5 - Omicron
    • D614G
    • P.1 - gamma
    • AA 1-681
    • AA 14-683
    • AA 16-685
    • AA 330-530
    • Asp614Gly
    • B.1.1.7 - alpha
    • B.1.617.1 - kappa
    • B.1.640
    • BA.2 - Omicron
    • BA.2.12.1 - Omicron
    • BA.2.75 - Omicron
    • C-Term
    • C.37 - Lambda
    • Deltacron
    • E484K
    • G476S
    • K417N
    • NTD
    • V367F
    • V483A
    • W436R
  • Konjugat
    • His tag
    • Fc Tag
    • mFc Tag
    • His tag,AVI tag,Biotin
    • His-Avi Tag
    • Fc-Avi Tag
    • His-Avi Tag,Biotin
    • Fc-Avi Tag,Biotin
    • Unkonjugiert
    • Biotin
    • Fc-His Tag
    • GST tag,His tag
    • His tag,Biotin
    • His tag,Fc Tag
    • His tag,SEKDEL Tag
    • His-DYKDDDDK Tag
    • sFc-Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Hersteller
    • antibodies-online
    • ACROBiosystems
    • ProSci
    • RayBiotech

Aktuelle Publikationen für unsere SARS-CoV-2 Spike S1 Proteine

Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." in: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

Fan, Parr, Kang, Gupta: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." in: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).

Kaneko, Satta, Komuro, Muthukrishnan, Kakarla, Guo, An, Elahi, Kornblum, Liebeskind, Hsiai, Hinman: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." in: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).

Sasisekharan, Pentakota, Jayaraman, Tharakaraman, Wogan, Narayanasami: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." in: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Narang, James, Balmer, Wilson: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." in: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).

Fiedler, Piziorska, Denninger, Morgunov, Ilsley, Malik, Schneider, Devenish, Meisl, Kosmoliaptsis, Aguzzi, Fiegler, Knowles: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." in: ACS infectious diseases, (2021) (PubMed).

Lucas, Klein, Sundaram, Liu, Wong, Silva, Mao, Oh, Mohanty, Huang, Tokuyama, Lu, Venkataraman, Park, Israelow, Vogels, Muenker, Chang, Casanovas-Massana, Moore, Zell, Fournier, Wyllie, Campbell, Lee et al.: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." in: Nature medicine, (2021) (PubMed).

Song, Bartley, Chow, Ngo, Jiang, Zamecnik, Dandekar, Loudermilk, Dai, Liu, Sunshine, Liu, Wu, Hawes, Alvarenga, Huynh, McAlpine, Rahman, Geng, Chiarella, Goldman-Israelow, Vogels, Grubaugh et al.: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." in: Cell reports. Medicine, pp. 100288, (2021) (PubMed).

Guo, Huang, Zhang, Yao, Zhou, Shen, Shen, Li, Li, Zhang, Chen, Chen, Wu, Fu, Zeng, Feng, Pi, Wang, Zhou, Lu, Li, Fang, Lu, Hu, Wang, Zhang, Gao, Adrian, Wang, Yu, Peng, Gabibov, Min, Wang, Huang et al.: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." in: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).

Aliase für SARS-CoV-2 Spike S1 Proteine

Surface Glycoprotein (S) Proteine
E2 Proteine
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