anti-AXL (AXL) Antikörper

Human AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. pharmacological inhibition of AXL specifically decreased the metastatic burden of mice developing HER2(+) breast cancer.

2. data do not support a particular role for TAM receptors or for activated CD11b in the association of platelet-derived EVs with monocytes and granulocytes in the circulation.

3. These data demonstrated that AXL promotes epirubicin resistance through transcriptional upregulation of c-MYC in esophageal adenocarcinoma cells.

4. AXL activation-induced cell softening promotes malignant progression.

5. The PROS1-AXL pathway regulates intrinsic mesenchymal signaling.

6. Axl kinase drives immune checkpoint and chemokine signaling pathways in lung adenocarcinomas.

7. We report for the first time that (1) the apoptotic cell recognition receptor Axl is exclusively expressed by human airway/alveolar macrophages, (2) Axl expression depends on the presence of type I/III IFNs, (3) increased shedding of sAxl occurs in sputum from patients with moderate-to-severe asthma, and (4) Axl mRNA expression in airway macrophages isolated from sputum is reduced in patients w/ moderate-to-severe asthma

8. We demonstrate that AXL is unlikely to function as an entry receptor for ZIKV and may instead promote ZIKV infection in human astrocytes by antagonizing type I IFN signalling.

9. Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation

10. OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling.

11. By eliminating distinct populations in heterogeneous melanoma cell pools, AXL-107-MMAE and MAPK pathway inhibitors cooperatively inhibited tumor growth. Furthermore, by inducing AXL transcription, BRAF/MEK inhibitors potentiated the efficacy of AXL-107-MMAE.

12. Study using gastric cancer (GC) tissue samples and mouse xenograft model showed that GAS6-AS1 can control the expression of its cognate sense gene GAS6 at the transcriptional or translational levels by forming a RNA-RNA duplex, significantly driving the aggressive GC phenotype, and consequently inducing an increase of AXL level and promoting AXL signaling pathway activation.

13. We emphasize a correlation between free Gas6 and free sAxl levels favoring abundant Gas6/Axl signaling in advanced fibrosis and hepatocellular carcinoma (HCC). The raised scenario provides a solid basis for theranostics allowing the use of sAxl as an accurate diagnostic biomarker of liver cirrhosis and HCC, as well as Axl receptor signaling for therapeutic intervention in stratified HCC patients.

14. Results found that prenatal tobacco smoke exposure was associated with the regulation of AXL, a receptor tyrosine kinase of the TAM family that plays an important role in suppressing Toll-like receptor-induced inflammation. Moreover, AXL methylation and tobacco smoke exposure during fetal development may act synergistically to modify the risk of bronchitis symptoms in childhood.

15. AXL is a key upstream effector of AKT pathway-associated resistance to BRAF inhibitors in melanomas with wildtype PTEN, but not in melanomas with impaired PTEN.The activated AXL kinase is required for acquired resistance to BRAF inhibitors in melanoma with wildtype PTEN.

16. sAXL is widely expressed in malignant effusions, particularly in ovarian and breast carcinoma and in malignant mesothelioma. sAXL is overexpressed in HGSC compared to LGSC and its levels are lower following exposure to chemotherapy.

17. AXL receptor tyrosine kinase (Axl) expression was induced by E6 protein, human papillomavirus-16 (HPV16E6) in cervical cancer cells, suggesting that blockade of Axl signalling might be an effective way to reduce the progression of cervical cancer.

18. AXL was highly expressed in clinical specimens of EGFR-mutated lung cancers and its high expression was associated with a low response rate to EGFR-tyrosine kinase inhibitor. These results indicated pivotal roles for AXL and its inhibition in the intrinsic resistance to osimertinib and the emergence of osimertinib-tolerant cells.

19. Axl/Akt/NF-kappaB signaling participates in mediating the effect of mineral trioxide aggregate on macrophage polarization.

20. The role of AXL in the esophageal adenocarcinoma cell invasion through upregulation of extracellular acidification, lysosomes peripheral distribution, and exocytosis.

Mouse (Murine) AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. These studies support a role for Axl inhibition in managing glomerulonephritis.

2. Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation

3. Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

4. ALX-deficient macrophages have defective microparticle clearance resulting in lung inflammation and injury.

5. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.

6. AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.

7. present findings indicate that MafB enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages

8. Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM receptor signaling.

9. This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.

10. These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.

11. GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.

12. Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.

13. reciprocal activation of Axl and Mer receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

14. Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.

15. Axl, Mertk and Tyro3 receptors are not required for Zika virus entry and infection.

16. Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.

17. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.

18. Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.

19. Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.

20. results establish TAM receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

Cow (Bovine) AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. activation of receptor tyrosine kinase Axl inhibits the osteogenic differentiation of vascular pericytes.