anti-AXL (AXL) Antikörper

Human AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. We demonstrate that AXL is unlikely to function as an entry receptor for ZIKV and may instead promote ZIKV infection in human astrocytes by antagonizing type I IFN signalling.

2. Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation

3. OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling.

4. By eliminating distinct populations in heterogeneous melanoma cell pools, AXL-107-MMAE and MAPK pathway inhibitors cooperatively inhibited tumor growth. Furthermore, by inducing AXL transcription, BRAF/MEK inhibitors potentiated the efficacy of AXL-107-MMAE.

5. Study using gastric cancer (GC) tissue samples and mouse xenograft model showed that GAS6-AS1 can control the expression of its cognate sense gene GAS6 at the transcriptional or translational levels by forming a RNA-RNA duplex, significantly driving the aggressive GC phenotype, and consequently inducing an increase of AXL level and promoting AXL signaling pathway activation.

6. We emphasize a correlation between free Gas6 and free sAxl levels favoring abundant Gas6/Axl signaling in advanced fibrosis and hepatocellular carcinoma (HCC). The raised scenario provides a solid basis for theranostics allowing the use of sAxl as an accurate diagnostic biomarker of liver cirrhosis and HCC, as well as Axl receptor signaling for therapeutic intervention in stratified HCC patients.

7. Results found that prenatal tobacco smoke exposure was associated with the regulation of AXL, a receptor tyrosine kinase of the TAM family that plays an important role in suppressing Toll-like receptor-induced inflammation. Moreover, AXL methylation and tobacco smoke exposure during fetal development may act synergistically to modify the risk of bronchitis symptoms in childhood.

8. AXL is a key upstream effector of AKT pathway-associated resistance to BRAF inhibitors in melanomas with wildtype PTEN, but not in melanomas with impaired PTEN.The activated AXL kinase is required for acquired resistance to BRAF inhibitors in melanoma with wildtype PTEN.

9. sAXL is widely expressed in malignant effusions, particularly in ovarian and breast carcinoma and in malignant mesothelioma. sAXL is overexpressed in HGSC compared to LGSC and its levels are lower following exposure to chemotherapy.

10. AXL receptor tyrosine kinase (Axl) expression was induced by E6 protein, human papillomavirus-16 (HPV16E6) in cervical cancer cells, suggesting that blockade of Axl signalling might be an effective way to reduce the progression of cervical cancer.

11. AXL was highly expressed in clinical specimens of EGFR-mutated lung cancers and its high expression was associated with a low response rate to EGFR-tyrosine kinase inhibitor. These results indicated pivotal roles for AXL and its inhibition in the intrinsic resistance to osimertinib and the emergence of osimertinib-tolerant cells.

12. Axl/Akt/NF-kappaB signaling participates in mediating the effect of mineral trioxide aggregate on macrophage polarization.

13. The role of AXL in the esophageal adenocarcinoma cell invasion through upregulation of extracellular acidification, lysosomes peripheral distribution, and exocytosis.

14. Decreased ARL2 expression level was clinically correlated to the higher grades and poorer outcomes of glioma patients. ARL2 overexpression attenuated the proliferation, clone formation, migration, invasive and tumorigenic capabilities of glioma cells by regulating the expression of receptor tyrosine kinase AXL.

15. Axl binds to and phosphorylates TNS2 and that Axl/TNS2/IRS-1 cross-talk may potentially play a critical role in glucose metabolism of cancer cells.

16. AXL expression is regulated by miR-34a.miR-34a regulates dendritic cells activation by targeting AXL.AXL expression is reduced in rheumatoid arthritis CD1c+ dendritic cells.

17. Axl induction during viral infections contributes to maintaining macrophage capacity to engulf apoptotic cells, which may have important consequences for resolution of anti-viral immune responses.

18. Serum soluble AXL is not a helpful biomarker for cardiovascular complications after heart transplantation.

19. miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3'-UTRs in triple-negative breast cancer.

20. identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity.

Mouse (Murine) AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation

2. Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

3. ALX-deficient macrophages have defective microparticle clearance resulting in lung inflammation and injury.

4. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.

5. AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.

6. present findings indicate that MafB enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages

7. Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM receptor signaling.

8. This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.

9. These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.

10. GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.

11. Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.

12. reciprocal activation of Axl and Mer receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

13. Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.

14. Axl, Mertk and Tyro3 receptors are not required for Zika virus entry and infection.

15. Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.

16. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.

17. Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.

18. Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.

19. results establish TAM receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

20. These results suggest that TAM receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.

Cow (Bovine) AXL Receptor tyrosine Kinase (AXL) Interaktionspartner

1. activation of receptor tyrosine kinase Axl inhibits the osteogenic differentiation of vascular pericytes.