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Chicken Monoclonal SREBF2 Primary Antibody für ELISA, GS - ABIN4355936
Janowski, Shan, Russell: The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. in The Journal of biological chemistry 2001
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Human Polyclonal SREBF2 Primary Antibody für ICC, IF - ABIN261631
Huster, Purnat, Burkhead, Ralle, Fiehn, Stuckert, Olson, Teupser, Lutsenko: High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. in The Journal of biological chemistry 2007
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Human Monoclonal SREBF2 Primary Antibody für ChIP, WB - ABIN2668815
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. in PLoS ONE 2014
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Human Polyclonal SREBF2 Primary Antibody für ICC, IF - ABIN4355940
Mast, Lin, Anderson, Bjorkhem, Pikuleva: Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). in PLoS ONE 2017
Human Polyclonal SREBF2 Primary Antibody für IP, WB - ABIN4355938
Karanth, Tran, Kuberan, Schlegel: Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. in Disease models & mechanisms 2013
Hexacosanol activates AMPK (zeige PRKAA1 Antikörper) and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
increase in SREBP-2 directly activates expression of patatin-like phospholipase domain-containing enzyme 8 (PNPLA8 (zeige PNPLA8 Antikörper)) gene, and PNPLA8 (zeige PNPLA8 Antikörper) associates with autophagosomes and is associated with a decrease in cellular triglyceride
Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis.
The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (zeige NR1H3 Antikörper) activity and SREBP-1c (zeige SREBF1 Antikörper) expression.
Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate.
SIRT1 (zeige SIRT1 Antikörper) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (zeige AKT1 Antikörper) signalling pathway, suggesting that SIRT1 (zeige SIRT1 Antikörper) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR Antikörper) that via p38 MAPK (zeige MAPK14 Antikörper) and caspase-3 (zeige CASP3 Antikörper) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB Antikörper) and pro-NGF (zeige NGFB Antikörper).
This study reveals SHP (zeige LAMC1 Antikörper) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 Antikörper).
SREBF2 polymorphism rs2269657 showed significant dual associations with LOAD pathological biomarkers and gene expression levels. Furthermore, SREBF2 expression levels measured in LOAD frontal cortices inversely correlated with age at death; suggesting a possible influence on survival rate.
SREBP-2 regulates autophagy-related gene expression in human liver cells.
High SREBP-2 expression is associated with hypercholesterolemia.
By altering the membrane trafficking through the lysosomes, cholesterol redistributes and regulates SREBP-2.
The gene polymorphism of SREBP2 not only significantly associated with the clinical phenotypes of osteonecrosis of the femoral head but also closely related to lipid metabolism disorder.
The current investigation indicated that the rs2267439C/T polymorphism in the SREBF-2 gene increased the T2D susceptibility in an Iranian population.
CpG sites located in SREBF2 gene showed differential methylation in association with total cholesterol. The expression of the SREBF2 was inversely associated with methylation of its corresponding CpGs.
Acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients.
these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and prostate cancer metastasis
dysregulation of SIRT1 (zeige SIRT1 Antikörper)-AMPK (zeige PRKAA1 Antikörper)-SREBP and stimulation of NLRP3 (zeige NLRP3 Antikörper) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (zeige KLF13 Antikörper) and SREBP-Sp1 (zeige SP1 Antikörper) activation interact to regulate low density lipoprotein receptor (zeige LDLR Antikörper) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2