anti-CTGF (CTGF) Antikörper

Mouse (Murine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. our data identify tumor cell-derived CTGF as a keystone in the hepatocellular carcinoma (HCC) microenvironment, activating nearby Hepatic stellate cells (HSC) that transmit progrowth signals to HCC cells, and this interaction is susceptible to inhibition by an anti-CTGF antibody

2. High CTGF expression is associated with peritoneal fibrosis.

3. Secretion of CCN2 by cardiomyocytes is not pro-fibrotic, while fibroblast-derived CCN2 can modulate fibrosis in the heart. In conclusion we found that cardiomyocyte-derived CCN2 is dispensable for cardiac fibrosis, while inhibiting CCN2 induction in activated fibroblasts is sufficient to abrogate the cardiac fibrotic response to angiotensin II

4. results show that the myofibers are critical mediators of the deleterious effects associated with CTGF in Muscular dystrophy and acutely injured skeletal muscle.

5. EGFR regulates CCN2 fibrotic signalling in the kidney.

6. miR-18a was decreased during lung fibrosis in vitro and in vivo, as well as in patients with IPF. Moreover, knockdown of miR-18a led to fibrogenesis in lung fibroblasts, whereas enhanced expression of miR-18a attenuated TGF-beta1-induced lung fibrosis by directly targeting the regulation of connecting tissue growth factor.

7. we also found that CTGF/CCN2 is expressed in astrocytes and neurons, predominantly in dorsal areas of spinal cord from symptomatic hSOD1G93A mice. Together, these results reveal that CTGF/CCN2 might be a novel therapeutic target to ameliorate symptoms and improve the quality of life of ALS patients.

8. Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis.

9. These results reveal a novel mechanism of macrophage migration into glomeruli with nephritis mediated by connective tissue growth factor derived from mesangial cells.

10. miR-26b-5p interacted with 3'UTRs of Col1a2 and CTGF, and circ_000203 could block the interactions of miR-26b-5p and 3'UTRs of Col1a2 and CTGF.

11. early myocardial CTGF mRNA expression (six hours) after Ang-II exposure is likely dependent on latent TGF-beta activation via the canonical Smad-dependent pathway in resident cardiac cells.

12. These results indicate that the hepatocytic expression of TGF-beta and CTGF is mediated by Wnt signalling in Schistosoma japonicum infection.

13. Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.

14. The data demonstrate that MMP13 and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.

15. p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF exp p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF expression during tooth development.

16. Ctgf is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells.

17. As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C.

18. CTGF and BMP2 are induced following myocardial ischemia in mice and humans.

19. this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin overexpression and preventing podocyte EMT, which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.

20. LPA-LPA1 signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.

Human Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. results show that GAS5 serves as a sponge for miR-18a, inhibiting its capability to suppress CTGF protein translation and ultimately decreasing the adipogenic differentiation of Mesenchymal stem cells.

2. TGFbeta1, collagen, and CTGF are expressed in the stroma of adenomyotic endometria and demonstrate that TGFbeta1 can induce collagen production in endometrium-derived fibroblasts through cellular Smad2/3-dependent signaling pathway and CTGF expression, suggesting that endometrial TGFbeta may take part in the pathogenesis of adenomyosis and ectopic endometrium may participate in uterine adenomyosis.

3. the enhanced CTGF expression in asthmatic-airway smooth muscle may contribute to airway remodelling in asthma.

4. cTGF is highly expressed in Human Epicardial Adipose Tissue and associated with atrial fibrosis, and can be an important risk factor for Atrial Fibrillation .

5. In the human amygdala, CTGF expression was significantly increased in major depressive disorder compared with control subjects.

6. Our findings demonstrate that CTGF is an essential downstream mediator for TGF-b1-induced extracellular matrix production and myofibroblast transdifferentiation in Graves' orbital fibroblasts and thus may provide with a potential therapeutic target for treatment of GO

7. TGF-beta 1 can promote CTGF, collagen type, collagen type gene level and protein expression in ligamentum flavum cells, and TGF-beta 1 can synergistically promote proliferation of ligamentum flavum cells through CTGF

8. our data identify tumor cell-derived CTGF as a keystone in the hepatocellular carcinoma (HCC) microenvironment, activating nearby Hepatic stellate cells (HSC) that transmit progrowth signals to HCC cells, and this interaction is susceptible to inhibition by an anti-CTGF antibody

9. ADAM17/EGFR-dependent ERK activation mediated thrombin-stimulated CTGF expression in human lung fibroblasts.

10. TGF-beta 1/CTGF based on the p38 MAPK signaling pathway play an important role in the occurance and development of hypertrophy of human lumbar ligamentum flavum.

11. connective tissue growth factor (CTGF) was the target gene regulated by miR-133b.

12. Here it is demonstrated that S1P activates YAP and that the S1P receptor 2 (S1PR2/S1P2) mediates S1P-induced YAP activation in both human and mouse hepatocellular carcinoma (HCC) cells. S1P promotes YAP-mediated upregulation of cysteine-rich protein 61 and connective tissue growth factor (CTGF), and stimulates HCC cell proliferation

13. Results provide new insights into the cross-talk among different cell types in the tumor microenvironment and suggest cancer-associated fibroblasts (CAFs) play an unappreciated role in melanoma metastasis and progression by being essential for tumor neovascularization via the production of CCN2.

14. In conclusion, circulating levels of CCN2 measured in the acute phase of STEMI were not associated with final infarct size, left ventricular function or new clinical events.

15. Inhibiting CTGF could improve inflammatory response.

16. miR-145 suppressed the progression of AAD [acute aortic dissection] by targeting CTGF [connective tissue growth factor], suggesting that a miR-145/CTGF axis may provide a potential therapeutic target for AAD.

17. tumor-secreted CTGF/VEGFA alone is sufficient to activate paired mammary fibroblasts from the same patient via ROCK1 and JunB signaling.

18. CCN2 is synthesized and secreted as a preproprotein that is autoinhibited by its two N-terminal domains and requires proteolytic processing and homodimerization to become fully biologically active.

19. In regards to extracellular matrix remodelling, treprostinil significantly reduced PDGF-BB-TGF-beta1-CTGF induced synthesis and deposition of collagen type I and fibronectin, in a cAMP sensitive manner

20. Curcumin can suppress TGF-beta1-induced CTGF expression in human gingival fibroblasts through the interruption of Smad2 signaling.

Cow (Bovine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. Bovine CCN2 exhibits unique expression patterns during preimplantation development, and is required for the proper expression of key regulatory genes in bovine blastocysts.

2. Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.

3. The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low.

4. Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability

Zebrafish Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.

2. this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.

3. CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development

Xenopus laevis Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2-, GFAP-and GFAP/Nestin-positive cells, activated p44/42 signaling, and upregulated fibronectin. In human glioma cells, it induced GFAP and nestin.

2. Data show that connective-tissue growth factor regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6).

Rhesus Monkey Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.

Rabbit Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. A significant increase in TGF-beta1 and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.

2. Stretch is an important primary trigger for CTGF-induction in the overloaded heart.

3. Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.

4. TGF-beta1 can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.

5. Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.

Pig (Porcine) Connective Tissue Growth Factor (CTGF) Interaktionspartner

1. CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.

2. Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.

3. CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.

4. CTGF level was not altered in model of obliterative bronchiolitis.