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anti-Human CLEC2D Antikörper:
anti-Mouse (Murine) CLEC2D Antikörper:
anti-Rat (Rattus) CLEC2D Antikörper:
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Human Monoclonal CLEC2D Primary Antibody für IHC (p), ELISA - ABIN565412
Roth, Mittelbronn, Wick, Meyermann, Tatagiba, Weller: Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1. in Cancer research 2007
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Human Monoclonal CLEC2D Primary Antibody für FACS - ABIN4897676
Chalan, Bijzet, Huitema, Kroesen, Brouwer, Boots: Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis. in PLoS ONE 2015
Show all 2 Pubmed References
Human Monoclonal CLEC2D Primary Antibody für ELISA, WB - ABIN949236
Williams, Eaton, Jones, Rengan, Burshtyn: Vaccinia virus Western Reserve induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D. in Microbiology and immunology 2016
Human Polyclonal CLEC2D Primary Antibody für CyTOF, FACS - ABIN4900423
Llibre, Garner, Partridge, Freeman, Klenerman, Willberg: Expression of lectin-like transcript-1 in human tissues. in F1000Research 2017
Human Monoclonal CLEC2D Primary Antibody für FACS - ABIN4897677
Dupuy, Lambert, Zucman, Choukem, Tognarelli, Pages, Lebbé, Caillat-Zucman: Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. in PLoS pathogens 2012
These results show that susceptibility of normal articular chondrocytes to lysis by NK cells is modulated by NKR-P1A (zeige KLRB1 Antikörper)/LLT1 interactions. Thus, NKR-P1A (zeige KLRB1 Antikörper)/LLT1 interaction might provide some novel target for therapeutic interventions in the course of pathological cartilage injury.
Blocking LLT1-NKRP1A (zeige KLRB1 Antikörper) interaction will make prostate cancer cells susceptible to killing by NK cells, suggesting a therapeutic option for treatment of prostate cancer.
these data suggest that LLT1-CD161 (zeige KLRB1 Antikörper) interactions play a novel and important role in B cell maturation (zeige TNFRSF17 Antikörper) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (zeige MBL2 Antikörper)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (zeige KLRB1 Antikörper) have roles in modulating immune responses to pathogens; and interferon-gamma (zeige IFNG Antikörper) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (zeige KLRB1 Antikörper) protein (NKRP1A/KLRB1 (zeige KLRB1 Antikörper)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (zeige SRC Antikörper)-PTK, p38 (zeige CRK Antikörper) and ERK (zeige EPHB2 Antikörper) signalling pathways, but not PKC (zeige PRRT2 Antikörper), PI3K (zeige PIK3CA Antikörper) or calcineurin pathways, to increase production of IFN-gamma (zeige IFNG Antikörper) by human natural killer cells.
these findings demonstrate that Clr-b is an IFN-stimulated gene on healthy bystander cells, in addition to a missing-self marker on MCMV-infected cells, and thereby enhances the dynamic range of innate self-nonself discrimination by NK cells
Data suggest that killer cell lectin-like receptors NKR (zeige TACR3 Antikörper)-P1B:Clr-b (Klrb1 (zeige KLRB1 Antikörper):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (zeige IFNG Antikörper) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (zeige CA2 Antikörper)+)/CaMK II (zeige CAMK2B Antikörper), and MAPK (zeige MAPK1 Antikörper) signaling pathways.
Identification of a novel family of genes, named Clr (zeige CALCR Antikörper), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
C-type lectin domain family 2 member D
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, osteoclast inhibitory lectin
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin domain family 2 member D5
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member H-like