PUMA Produkte
(BCL2 Binding Component 3 (BBC3))
Kategorien
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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Ausgewählte PUMA Kategorien
PUMA Antikörper
High quality antibodies with extensive validation data.
PUMA ELISA Kits
Reliable ELISA kits for a wide range of species.
PUMA Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PUMA Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN7101572
Menge
20 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ICC, IF
Validierungen
- (6)
Kat. Nr.
ABIN361748
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Pig, Rat
Applikation
WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (3)
- (4)
Kat. Nr.
ABIN731528
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PUMA ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969127
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969126
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6954053
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PUMA Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121980
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2730162
Menge
20 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7504951
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PUMA Produkten
: "Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation." in: Cancer cell, Vol. 35, Issue 2, pp. 191-203.e8, (2019) (PubMed).: "Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis." in: The Journal of biological chemistry, Vol. 294, Issue 35, pp. 12957-12974, (2019) (PubMed).
: "Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells." in: International journal of molecular sciences, Vol. 17, Issue 5, (2017) (PubMed).
: "Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival." in: The Journal of biological chemistry, Vol. 291, Issue 37, pp. 19545-57, (2016) (PubMed).
: "Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway." in: Acta pharmacologica Sinica, Vol. 36, Issue 12, pp. 1514-9, (2016) (PubMed).
: "Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, pp. 1-7, (2015) (PubMed).
: "p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death." in: Oncogene, (2015) (PubMed).
: "Nerve growth factor reduces apoptotic cell death in rat facial motor neurons after facial nerve injury." in: Neurosciences (Riyadh, Saudi Arabia), Vol. 20, Issue 1, pp. 65-8, (2015) (PubMed).
: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." in: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).
: "A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53." in: Cancer letters, Vol. 356, Issue 2 Pt B, pp. 910-7, (2014) (PubMed).
Synonyme und alternative Namen zu PUMA
BCL2 binding component 3 (BBC3), Bcl-2 binding component 3 (Bbc3), BCL2 binding component 3 (Bbc3), BCL2 binding component 3 (bbc3), BBC3, JFY-1, JFY1, Puma, PUMA, PUMA/JFY1Bezeichner auf Proteinebene für PUMA
- BCL2 binding component 3
- bcl-2-binding component 3
- p53 up-regulated modulator of apoptosis
- BH3-only
- Bcl-2 binding component 3
- Puma
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