IL1A Protein

Produktnummer ABIN7849710

Recombinant IL1A-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für IL1A Protein (ABIN7849710)

Target: IL1A (Interleukin 1 alpha (IL1A))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: >95 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Mouse IL-1a Protein

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: <1 EU/μg by LAL test

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration<100 μg/mL.)

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 6 % Sucrose, 2 %Mannitol, 50 mM Arginine, 0.03 % Tween80, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Antigendetails

Target: IL1A (Interleukin 1 alpha (IL1A))

Andere Bezeichnung: IL-1a

Hintergrund:

Synonyms: IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α

Description: Recombinant mouse IL-1a is produced by the E.coli system, with the target gene encoding Ser115-Ser270 expressed.

Background: Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene.In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.

UniProt: P01583

Pathways: NF-kappaB Signalweg, Autophagie, Cancer Immune Checkpoints