IL1A Protein

Produktnummer ABIN7849667

Dieses Recombinant IL1A-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für IL1A Protein (ABIN7849667)

Target: IL1A (Interleukin 1 alpha (IL1A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS), ELISA

Reinheit: >90 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Human Interleukin-1 alpha, IL1A Protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Tris-HCl, pH 7.4±0.2.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Antigendetails

Target: IL1A (Interleukin 1 alpha (IL1A))

Andere Bezeichnung: IL1A

Hintergrund:

Synonyms: Interleukin-1 alpha, IL1A, IL-1 alpha, Hematopoietin-1, IL1F1, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha.

Description: Recombinant human IL-1 alpha protein.

Background: Interleukin-1 alpha (IL-1α) is a protein of the interleukin-1 family that in humans is encoded by the IL1A gene which spans 10.2 kb and has 7 exons. It is 1 of 2 structurally distinct forms of IL1, the other being IL1B, this two proteins are synthesized by a variety of cell types, including activated macrophages, keratinocytes, stimulated B lymphocytes, and fibroblasts, and are potent mediators of inflammation and immunity. IL1A may play a role in the genesis of inflammation by augmenting the transcription of proinflammatory genes, a mechanism not affected by extracellular inhibitors. IL1A has been administered to patients during receiving autologous bone marrow transplantation.

Pathways: NF-kappaB Signalweg, Autophagie, Cancer Immune Checkpoints