IL-21 Protein (AA 23-155)

Produktnummer ABIN7566234

Dieses Recombinant IL-21-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für IL-21 Protein (AA 23-155) (ABIN7566234)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: >95 % (SDS-PAGE)

Produktdetails

Proteineigenschaft: AA 23-155

Verwendungszweck: IL-21 (human) (rec.) (untagged)

Kreuzreaktivität: Human

Produktmerkmale: Human IL-21 (aa 23-155) with a N-terminal Met.

Sterilität: Sterile filtered

Endotoxin-Niveau: <0.01EU/μg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its ability to induce interferon-gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.4-2ng/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1 % BSA should be used for further dilutions.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -80°C

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Andere Bezeichnung: IL-21

Hintergrund:

Interleukin-21

Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.

Molekulargewicht: ~17kDa (SDS-PAGE)

UniProt: Q9HBE4-1

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response