IDO1 Protein

Produktnummer ABIN7520080

Dieses Recombinant IDO1-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für IDO1 Protein (ABIN7520080)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 97 % by SDS-PAGE.

Produktdetails

Verwendungszweck: Active Recombinant Human IDO-1 Protein

Sequenz: AHAMENSWTI SKEYHIDEEV GFALPNPQEN LPDFYNDWMF IAKHLPDLIE SGQLRERVEK LNMLSIDHLT DHKSQRLARL VLGCITMAYV WGKGHGDVRK VLPRNIAVPY CQLSKKLELP PILVYADCVL ANWKKKDPNK PLTYENMDVL FSFRDGDCSK GFFLVSLLVE IAAASAIKVI PTVFKAMQMQ ERDTLLKALL EIASCLEKAL QVFHQIHDHV NPKAFFSVLR IYLSGWKGNP QLSDGLVYEG FWEDPKEFAG GSAGQSSVFQ CFDVLLGIQQ TAGGGHAAQF LQDMRRYMPP AHRNFLCSLE SNPSVREFVL SKGDAGLREA YDACVKALVS LRSYHLQIVT KYILIPASQQ PKENKTSEDP SKLEAKGTGG TDLMNFLKTV RSTTEKSLLK EG

Spezifität: Ala2-Gly403

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Andere Bezeichnung: IDO-1

Hintergrund:

Description: Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Name: IDO, IDO-1, INDO,IDO1,IDO-1,INDO,indoleamine 2

Gen-ID: 3620

UniProt: P14902

Pathways: Activated T Cell Proliferation