Glypican 3 Protein (GPC3) (AA 25-559) (His tag)

Produktnummer ABIN7321025

Recombinant Glypican 3-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Glypican 3 Protein (GPC3) (AA 25-559) (His tag) (ABIN7321025)

Target: Glypican 3 (GPC3)

Protein-Typ: Recombinant

Spezies: Rhesusaffen

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 25-559

Aufreinigungstag / Konjugat: Dieses Glypican 3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rhesus Macaque Glypican-3/GPC3/OCI5 (C-6His)

Sequenz: Gln25-His559

Produktmerkmale: Recombinant Rhesus Macaque Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-His559 is expressed with a 6His tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Glypican 3 (GPC3)

Andere Bezeichnung: Glypican-3/GPC3/OCI5

Hintergrund: GPC3,GTR2-2,Glypican-3,Intestinal protein OCI-5,MXR7,OCI5,Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

Molekulargewicht:

Calculated MW: 61.6 kDa

Observed MW: 38&65-120 kDa

UniProt: F6TST2

Pathways: Glycosaminoglycan Metabolic Process