IL-3 Protein (His tag)

Produktnummer ABIN7320592

Dieses Recombinant IL-3-Protein wird in Human Cells exprimiert.

Kurzübersicht für IL-3 Protein (His tag) (ABIN7320592)

Target: IL-3 (Interleukin 3 (IL-3))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses IL-3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Interleukin-3/IL-3 Protein (His Tag)

Sequenz: Ala27-Cys166

Produktmerkmale: Recombinant Mouse Interleukin-3 is produced by our Mammalian expression system and the target gene encoding Ala27-Cys166 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL-3 (Interleukin 3 (IL-3))

Andere Bezeichnung: Interleukin-3/IL-3

Hintergrund:

Background: Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated mouse mast cells, mouse keratinocytes and neurons/astrocytes can also produce IL-3. IL-3 exerts its biological activities through binding to specific cell surface receptors. The high affinity receptor responsible for IL-3. signaling is composed of α and βsubunits. IL-3 is capable of supporting the proliferation of abroad range of hematopoietic cell types. It is involved in avariety of cell activities such as cell growth, differentiation and apoptosis. IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

Synonym: Interleukin-3, IL-3, Hematopoietic growth factor,Multipotential colony-stimulating factor, P-cell-stimulating factor, Il3, Il-3,Mast cell growth factor, MCGF

Molekulargewicht: 16.5 kDa

UniProt: P01586

Pathways: JAK-STAT Signalweg, Regulation of Carbohydrate Metabolic Process, Autophagie