IL1A Protein

Produktnummer ABIN7321259

Recombinant IL1A-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für IL1A Protein (ABIN7321259)

Target: IL1A (Interleukin 1 alpha (IL1A))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Rat IL-1A/ IL-1α Protein

Sequenz: Ser115-Ser270

Produktmerkmale: Recombinant Rat Interleukin-1 Alpha is produced by our E.coli expression system and the target gene encoding Ser115-Ser270 is expressed.

Endotoxin-Niveau: <1.0 EU per μg as determined by LAL test.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL1A (Interleukin 1 alpha (IL1A))

Andere Bezeichnung: IL-1A/ IL-1alpha

Hintergrund:

Background: Interleukin 1 (IL-1) is a name that designates two proteins, IL-1αand IL-1β, which are the products of distinct genes, but which show approximately 25 % amino acid (aa) sequence identity and which recognize the same cell surface receptors. IL-1αand IL-1β are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL-1α remains in the cytosol of cells, although there is evidence for a membranebound form of the precursor form of IL-1α. Although IL-1 production is generally considered to be a consequence of inflammation, evidence suggests that IL-1 is also temporally upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. In response to classic stimuli produced by inflammatory agents, infections or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cells is seen.

Synonym: Interleukin-1 alpha, IL-1 alpha, Il1a

Molekulargewicht: 17.9 kDa

UniProt: P16598

Pathways: NF-kappaB Signalweg, Autophagie, Cancer Immune Checkpoints