Glypican 3 Protein (GPC3) (His tag)

Produktnummer ABIN7320888

Dieses Recombinant Glypican 3-Protein wird in Human Cells exprimiert.

Kurzübersicht für Glypican 3 Protein (GPC3) (His tag) (ABIN7320888)

Target: Glypican 3 (GPC3)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: >95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Glypican 3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Glypican-3/GPC3/OCI5 (C-6His)

Sequenz: Gln25-Met557

Produktmerkmale: Recombinant Mouse Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-Met557 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Glypican 3 (GPC3)

Andere Bezeichnung: Glypican-3/GPC3/OCI5

Hintergrund:

Background: Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

Synonym: Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, GPC3, OCI5

Molekulargewicht: 61.6 kDa

UniProt: Q8CFZ4

Pathways: Glycosaminoglycan Metabolic Process