Clusterin Protein (CLU) (His tag)

Produktnummer ABIN7320262

Dieses Recombinant Clusterin-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für Clusterin Protein (CLU) (His tag) (ABIN7320262)

Target: Clusterin (CLU)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 96 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Clusterin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Clusterin/ApoJ Protein (His Tag)

Sequenz: Met 1-Glu 448

Produktmerkmale: A DNA sequence encoding the mouse CLU (NP_038520.2) (Met 1-Glu 448) was expressed, with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin/ApoJ

Hintergrund:

Background: Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Synonym: Clusterin,Apolipoprotein J,Clustrin,Sulfated glycoprotein 2,ApoJ, Cli, D14Ucla3, Sgp-2, Sgp2, SP-40,Sugp-2

Molekulargewicht: 50.8 kDa

NCBI Accession: NP_038520

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling