Clusterin Protein (CLU) (AA 23-449, Nuclear) (His tag)

Produktnummer ABIN1344142

Produktdetails

Target: Clusterin (CLU)

Protein-Typ: Recombinant

Proteineigenschaft: Nuclear, AA 23-449

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Clusterin Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Human

Produktmerkmale: Human nuclear clusterin (aa 23-449) is fused at the C-terminus to a His-tag.

Reinheit: >90 % (SDS-PAGE)

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: <1EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 3 months

Referenzen

Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: "Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages." in: Journal of leukocyte biology, Vol. 90, Issue 4, pp. 761-9, (2011) (PubMed).

Antigendetails

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin (CLU Produkte)

Synonyme: LOC100136120 Protein, clu Protein, MGC53055 Protein, zgc:73352 Protein, xclu Protein, MGC89163 Protein, CLU Protein, APO-J Protein, APOJ Protein, CLI Protein, CLU1 Protein, CLU2 Protein, KUB1 Protein, NA1/NA2 Protein, SGP-2 Protein, SGP2 Protein, SP-40 Protein, TRPM-2 Protein, TRPM2 Protein, DAG Protein, RATTRPM2B Protein, SP40 Protein, TRPM2B Protein, Trpm2 Protein, Trpmb Protein, AI893575 Protein, ApoJ Protein, Cli Protein, D14Ucla3 Protein, Sgp-2 Protein, Sgp2 Protein, Sugp-2 Protein, GP80 Protein, gpIII Protein, 40 Protein, clusterin-1 Protein, clusterin L homeolog Protein, clusterin Protein, Clusterin Protein, LOC100136120 Protein, clu.L Protein, clu Protein, CLU Protein, clus Protein, Clu Protein, LOC101113728 Protein

Hintergrund: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Molekulargewicht: ~45kDa (SDS-PAGE)

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling