NOTCH3 Protein (AA 40-467) (Fc Tag)

Produktnummer ABIN6992329

Produktdetails

Target: NOTCH3 (Notch 3 (NOTCH3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 40-467

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NOTCH3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Human NOTCH3 Protein, Fc Tag

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Lagerung: -20 °C

Antigendetails

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: NOTCH3 (NOTCH3 Produkte)

Hintergrund: Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Molekulargewicht: 71.4 kDa

NCBI Accession: NP_000426

Pathways: Notch Signalweg