TRAF2 Protein (GST tag)

Produktnummer ABIN6700717

Hersteller Produkt- Nr.: 009-001-hb1s

Dieses Recombinant TRAF2-Protein wird in Insect cells (Sf9) produziert.

Kurzübersicht für TRAF2 Protein (GST tag) (ABIN6700717)

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Insect cells (Sf9)

Applikation: Western Blotting (WB), SDS-PAGE (SDS)

Reinheit: >80%

Produktdetails

Aufreinigungstag / Konjugat: Dieses TRAF2 Protein ist gelabelt mit GST tag.

Hersteller Produkt- Nr.: 009-001-hb1s

Hersteller: Rockland

Verwendungszweck: TRAF2 recombinant protein-GST fusion Epitope

Aufreinigung: Recombinant full-length human TRAF2 was expressed by baculovirus in Sf9 insect cells using an N-Terminal his epitope. The purity was determined to be >80% by densitometry.

Anwendungsinformationen

Applikationshinweise:

Application Note: TRAF2 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. TRAF2 Protein is suitable for use in Western Blot. Expect a band approximately ~89 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: TRAF2 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Andere Bezeichnung: TRAF2

Hintergrund:

Synonyms: TRAP, TRAP3, MGC: 45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3

Background: TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-kB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2). TRAF2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, and NfkB Pathway research.

NCBI Accession: NM_021138

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteine