CD137 Protein (AA 24-211) (Fc Tag)
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- Target Alle CD137 (TNFRSF9) Proteine anzeigen
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 24-211
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses CD137 Protein ist gelabelt mit Fc Tag.
- Sequenz
- AA 24-211
- Produktmerkmale
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.7 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE).
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product TNFRSF9 Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (Fc-Avi Tag)
TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His tag)TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His-Avi Tag,Biotin)TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His tag)TNFRSF9 Spezies: Cynomolgus, Rhesusaffen Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (Fc-Avi Tag,Biotin)TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (mFc-His Tag)TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-211) protein (His tag)TNFRSF9 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 46-128) protein (His-DYKDDDDK-Strep II Tag)TNFRSF9 Spezies: Human Wirt: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) protein (His-DYKDDDDK-Strep II Tag)TNFRSF9 Spezies: Human Wirt: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) (Active) protein (Fc Tag)TNFRSF9 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
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- Target
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
- Andere Bezeichnung
- 4-1BB (TNFRSF9 Produkte)
- Hintergrund
- 4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
- Molekulargewicht
- 46.7 kDa
- NCBI Accession
- NP_001070976
- Pathways
- Cancer Immune Checkpoints
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