BAX Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2715165

Produktdetails

Target: BAX (BCL2-Associated X Protein (BAX))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses BAX Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Bax (transcript variant alpha) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: Bax (BAX Produkte)

Synonyme: BAX-ALPHA Protein, bax-A Protein, xBax Protein, xlbax Protein, BAX Protein, bax Protein, fj16e01 Protein, wu:fc50b10 Protein, wu:fj16e01 Protein, BCL2L4 Protein, zgc:112983 Protein, BCL2 associated X, apoptosis regulator Protein, BCL2-associated X protein L homeolog Protein, BCL2-associated X protein Protein, bcl2-associated X protein, a Protein, bcl2-associated X protein, b Protein, BAX Protein, bax.L Protein, bax Protein, baxa Protein, Bax Protein, baxb Protein

Hintergrund: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Molekulargewicht: 21 kDa

NCBI Accession: NP_620116

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response