Osteoactivin Protein (GPNMB) (His tag)

Produktnummer ABIN2566817

Recombinant Osteoactivin-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Osteoactivin Protein (GPNMB) (His tag) (ABIN2566817)

Target: Osteoactivin (GPNMB)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Western Blotting (WB)

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Osteoactivin Protein ist gelabelt mit His tag.

Produktmerkmale:

Measured by the ability of the immobilized protein to induce pro-MMP-9 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 4 - 16 μg/mL.

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB. For research use only.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -80 °C,-20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: Osteoactivin (GPNMB)

Andere Bezeichnung: Osteoactivin

Hintergrund: Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Molekulargewicht: 52.9 kDa

Gen-ID: 10457

UniProt: Q14956