Clusterin Protein (CLU) (His tag)

Produktnummer ABIN2566468

Dieses Recombinant Clusterin-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Clusterin Protein (CLU) (His tag) (ABIN2566468)

Target: Clusterin (CLU)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Western Blotting (WB)

Reinheit: >92 % as determined by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Clusterin Protein ist gelabelt mit His tag.

Produktmerkmale:

Measured by its ability to induce clustering of human clear cell carcinoma epithelial cells Caki-2. Measured by its ability to inhibit DTT (Dithiothreitol) induced BSA precipitation.

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB. For research use only.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -80 °C,-20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin

Hintergrund: Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N-glycosylated disulfide-linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Molekulargewicht: 50.9 kDa (Disulfide - linked heterodimer)

Gen-ID: 1191

NCBI Accession: NP_001822

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling