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Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) (Active) protein (Fc Tag) Protein

TIM 3 Spezies: Human Wirt: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181819
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle TIM3 (TIM 3) Proteine anzeigen
    TIM3 (TIM 3)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 22-200
    Spezies
    • 17
    • 7
    • 4
    • 1
    • 1
    • 1
    Human
    Quelle
    • 12
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TIM3 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 22-200
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.5 kDa. As a result of glycosylation, the protein migrates as 55-67 kDa under reducing (R) condition, and 110-134 kDa under non-reducing (NR) condition (SDS-PAGE).
    Reinheit
    >85 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Target
    TIM3 (TIM 3)
    Andere Bezeichnung
    TIM-3 (TIM 3 Produkte)
    Synonyme
    HAVCR2, MGC140131, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, TIM-3, Tim3, Timd3, tim3, hepatitis A virus cellular receptor 2, HAVCR2, Havcr2
    Substanzklasse
    Virus
    Hintergrund
    Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
    Molekulargewicht
    46.5 kDa
    NCBI Accession
    NP_116171
    UniProt
    Q8TDQ0
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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