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Membrane Metallo-Endopeptidase (MME) (AA 52-750) protein (Fc Tag) Protein

MME Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2181507
$308.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle MME Proteine anzeigen
    MME
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 52-750
    Spezies
    • 14
    • 5
    • 5
    Human
    Quelle
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses MME Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 52-750
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 107.3 kDa. The protein migrates as 120-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    MME
    Andere Bezeichnung
    Neprilysin (MME Produkte)
    Synonyme
    CALLA, CD10, NEP, SFE, 6030454K05Rik, C85356, Nep, neprilysin, membrane metalloendopeptidase, membrane metallo endopeptidase, membrane metallo-endopeptidase, MME, Mme
    Substanzklasse
    Chemical
    Hintergrund
    Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110- kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).
    Molekulargewicht
    106.8 kDa
    NCBI Accession
    NP_000893
    Pathways
    RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
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