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LIF Protein (AA 23-202)

This anti-LIF antibody (ABIN2181462) is a HEK-293 Cells antibody detecting LIF in . Suitable for Human.
Produktnummer ABIN2181462

Kurzübersicht für LIF Protein (AA 23-202) (ABIN2181462)

Target

Alle LIF Proteine anzeigen
LIF (Leukemia Inhibitory Factor (LIF))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 24
  • 20
  • 3
  • 3
  • 2
  • 2
  • 1
Human

Quelle

  • 32
  • 12
  • 4
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

>95 % as determined by SDS-PAGE.
  • Proteineigenschaft

    AA 23-202

    Marke

    ActiveMax®

    Sequenz

    AA 23-202

    Produktmerkmale

    rhLIF, with Gly-Pro at the N- terminus, has a calculated MW of 19.9 kDa. The predicted N-terminus is Ser 23. The reducing (R) protein migrates as 33-45 kDa.

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target

    LIF (Leukemia Inhibitory Factor (LIF))

    Andere Bezeichnung

    LIF

    Hintergrund

    Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

    Molekulargewicht

    19.9 kDa

    Pathways

    JAK-STAT Signalweg, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
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