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Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His tag) Protein

CSF1R Spezies: Human Wirt: HEK-293 Cells Recombinant >96 % as determined by SDS-PAGE.
Produktnummer ABIN2180910
$253.00
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  • Target Alle CSF1R Proteine anzeigen
    CSF1R
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 20-512
    Spezies
    • 21
    • 11
    • 4
    • 4
    • 2
    • 1
    • 1
    Human
    Quelle
    • 19
    • 9
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CSF1R Protein ist gelabelt mit His tag.
    Sequenz
    AA 20-512
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.1 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >96 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    CSF1R
    Andere Bezeichnung
    M-CSF R (CSF1R Produkte)
    Synonyme
    AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSF-R, M-CSFR, C-FMS, CSFR, FIM2, FMS, HDLS, PDGFRB, MGC89146, CSF-1-R, c-fms, mrfms, CSF1, M-CSF, csf1r, fms, panther, colony stimulating factor 1 receptor, macrophage colony-stimulating factor receptor, colony stimulating factor 1 receptor, a, Csf1r, CSF1R, m-csfr, csf1r, csf1ra
    Hintergrund
    Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
    Molekulargewicht
    55.3 kDa
    NCBI Accession
    NP_005202
    Pathways
    RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization
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