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CD19 Molecule (CD19) (AA 20-292) protein (Fc Tag) Protein

CD19 Spezies: Cynomolgus, Rhesusaffen Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
Produktnummer ABIN2180710
$451.00
Zzgl. Versandkosten $45.00
Lieferung in 11 Werktagen
  • Target Alle CD19 Proteine anzeigen
    CD19
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 20-292
    Spezies
    • 25
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Cynomolgus, Rhesusaffen
    Quelle
    • 19
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD19 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 20-292
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.7 kDa. The protein migrates as 66-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    CD19
    Andere Bezeichnung
    CD19 (CD19 Produkte)
    Synonyme
    B4, CVID3, AW495831, CD19, CD19 molecule, CD19 antigen, CD19, Cd19
    Hintergrund
    B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I  membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.
    Molekulargewicht
    56.7kDa
    UniProt
    F7F486
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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