Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

Activin A Receptor, Type IIB (ACVR2B) (AA 19-137) protein (His tag)

ACVR2B Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2180560
$286.00
Zzgl. Versandkosten $45.00
Lieferung in 11 Werktagen
  • Target Alle ACVR2B Proteine anzeigen
    ACVR2B
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 19-137
    Spezies
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Quelle
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ACVR2B Protein ist gelabelt mit His tag.
    Sequenz
    AA 19-137
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.5 kDa. The protein migrates as 25-32 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
  • Target
    ACVR2B
    Andere Bezeichnung
    ACVR2B (ACVR2B Produkte)
    Synonyme
    ACVR2B, XAR1, actr-iib, actriib, ACTRIIB, ActR-IIB, HTX4, ActRIIB, actr2b, actrIIb, wu:fj97d11, activin A receptor type 2B, activin A receptor type 2B L homeolog, activin A receptor type 2Ba, activin receptor IIB, ACVR2B, acvr2b, acvr2b.L, Acvr2b, acvr2ba
    Hintergrund
    Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).
    Molekulargewicht
    14.5 kDa
    NCBI Accession
    NP_001097
    Pathways
    Hormone Transport, Cancer Immune Checkpoints
Sie sind hier:
Kundenservice