Oncostatin M Protein (OSM) (AA 24-206)

Produktnummer ABIN2018306

Dieses Recombinant Oncostatin M-Protein wird in HEK-293T Cells exprimiert.

Kurzübersicht für Oncostatin M Protein (OSM) (AA 24-206) (ABIN2018306)

Target: Oncostatin M (OSM)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293T Cells

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Produktdetails

Proteineigenschaft: AA 24-206

Produktmerkmale: ED50 < 0.4 ng/mL, measured in a cell proliferation assay using NIH-3T3 cells.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Murine Oncostatin-M remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Murine Oncostatin-M should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Oncostatin M (OSM)

Andere Bezeichnung: Oncostatin-M (OSM)

Hintergrund: Oncostatin-M, also known as OSM, is a growth regulator belonging to the interleukin-6 group of cytokines. It is expressed mainly by monocytes, activated T cells and Kaposi's sarcoma cells. OSM signals through two types of receptors, one is composed of gp130 and LIFR, and the other is composed of gp130 and OSMR. OSM regulates IL-6, G-CSF and GM-CSF production, and thus is involved in hematopoiesis, neurogenesis and osteogenesis. OSM displays both stimulatory and inhibitory effects, so its categorization as pro-inflammatory or anti-inflammatory cytokine is still controversial.
Synonyms: OSM

Molekulargewicht: 10-40 kDa, observed by reducing SDS-PAGE.

UniProt: P53347

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion