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Oncostatin M Protein (OSM) (AA 25-205)

Dieses Recombinant Oncostatin M-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN2018300

Kurzübersicht für Oncostatin M Protein (OSM) (AA 25-205) (ABIN2018300)

Target

Alle Oncostatin M (OSM) Proteine anzeigen
Oncostatin M (OSM)

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 27
  • 5
  • 4
  • 3
  • 1
  • 1
Maus

Quelle

  • 20
  • 13
  • 2
  • 1
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as analyzed by SDS-PAGE and HPLC.
  • Proteineigenschaft

    AA 25-205

    Produktmerkmale

    ED50 < 10 ng/mL, measured by a cell proliferation assay using Rat Embryo Brain cells, corresponding to a specific activity of > 1x 10^5 units/mg.
    AA 25-205, expressed with an N-terminal Met.

    Endotoxin-Niveau

    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant Mouse Oncostatin M (rmOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmOSM remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    Haltbarkeit

    6 months
  • Target

    Oncostatin M (OSM)

    Andere Bezeichnung

    Oncostatin M(OSM)

    Hintergrund

    Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE.
    Synonyms: OSM

    Molekulargewicht

    20.5 kDa, observed by reducing SDS-PAGE.

    UniProt

    P53347

    Pathways

    JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
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