Oncostatin M Protein (OSM) (AA 25-205)
Kurzübersicht für Oncostatin M Protein (OSM) (AA 25-205) (ABIN2018300)
Target
Alle Oncostatin M (OSM) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 25-205
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Produktmerkmale
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ED50 < 10 ng/mL, measured by a cell proliferation assay using Rat Embryo Brain cells, corresponding to a specific activity of > 1x 10^5 units/mg.
AA 25-205, expressed with an N-terminal Met. -
Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Lyophilized recombinant Mouse Oncostatin M (rmOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmOSM remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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Haltbarkeit
- 6 months
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- Oncostatin M (OSM)
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Andere Bezeichnung
- Oncostatin M(OSM)
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Hintergrund
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Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE.
Synonyms: OSM -
Molekulargewicht
- 20.5 kDa, observed by reducing SDS-PAGE.
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UniProt
- P53347
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Pathways
- JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
Target
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