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Oncostatin M Protein (OSM) (AA 26-234)

Dieses Recombinant Oncostatin M-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN2018297

Kurzübersicht für Oncostatin M Protein (OSM) (AA 26-234) (ABIN2018297)

Target

Alle Oncostatin M (OSM) Proteine anzeigen
Oncostatin M (OSM)

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 26
  • 6
  • 4
  • 3
  • 1
  • 1
Human

Quelle

  • 20
  • 13
  • 2
  • 1
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as analyzed by SDS-PAGE and HPLC.
  • Proteineigenschaft

    AA 26-234

    Produktmerkmale

    ED50 < 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x 10^5 units/mg.
    AA 26-234, expressed with an N-terminal Met.

    Endotoxin-Niveau

    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant human Oncostatin M(209 a.a.) (rhOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    Haltbarkeit

    6 months
  • Target

    Oncostatin M (OSM)

    Hintergrund

    Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant human Oncostatin M(209 a.a.) (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 210 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 23.8 kDa analyzed by reducing SDS-PAGE.
    Synonyms: OSM

    Molekulargewicht

    23.8 kDa, observed by reducing SDS-PAGE.

    UniProt

    P13725

    Pathways

    JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
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