Oncostatin M Protein (OSM) (AA 26-234)
Kurzübersicht für Oncostatin M Protein (OSM) (AA 26-234) (ABIN2018297)
Target
Alle Oncostatin M (OSM) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
-
-
Proteineigenschaft
- AA 26-234
-
Produktmerkmale
-
ED50 < 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x 10^5 units/mg.
AA 26-234, expressed with an N-terminal Met. -
Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
-
-
Möchten Sie weitere Optionen für dieses Protein ?
!Entdecken Sie unsere vordefinierten maßgeschneiderten Proteine und Proteinservices!Ihr Projekt erfordert weitere Anpassungen? Kontaktieren Sie uns und entdecken Sie unsere maßgeschneiderten Proteinlösungen
-
-
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
-
Buffer
- Lyophilized after extensive dialysis against PBS.
-
Lagerung
- -80 °C
-
Informationen zur Lagerung
- Lyophilized recombinant human Oncostatin M(209 a.a.) (rhOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
-
Haltbarkeit
- 6 months
-
-
- Oncostatin M (OSM)
-
Hintergrund
-
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant human Oncostatin M(209 a.a.) (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 210 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 23.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: OSM -
Molekulargewicht
- 23.8 kDa, observed by reducing SDS-PAGE.
-
UniProt
- P13725
-
Pathways
- JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
Target
-