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IL-3 Protein (AA 20-152)

Recombinant IL-3-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN2018100

Kurzübersicht für IL-3 Protein (AA 20-152) (ABIN2018100)

Target

Alle IL-3 Proteine anzeigen
IL-3 (Interleukin 3 (IL-3))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 23
  • 16
  • 5
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 30
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as analyzed by SDS-PAGE and HPLC.
  • Proteineigenschaft

    AA 20-152

    Produktmerkmale

    ED50 < 0.5 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 2 x 10^7 units/mg.
    AA 20-152, expressed with an N-terminal Met.

    Endotoxin-Niveau

    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstituted in ddH2O at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Lyophilized recombinant human Interleukin-3 (rhIL-3) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-3 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    Haltbarkeit

    6 months
  • Target

    IL-3 (Interleukin 3 (IL-3))

    Andere Bezeichnung

    Interleukin-3 (IL-3)

    Hintergrund

    Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 shares similarities with Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and IL-5: they all have a four-helix bundle structure, are located on the same chromosomes in both human and mouse, are produced by activated T cells, and share receptors. The IL-3/IL-5/GM-CSF receptor family members are all heterodimeric, composed of a receptor-specific alpha chain and a common beta chain. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. Recombinant human Interleukin-3 (rhIL-3) produced in E. coli is a single non-glycosylated polypeptide chain containing of 134 amino acids. A fully biologically active molecule, rhIL-3 has a molecular mass of 15.2 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor

    Molekulargewicht

    15.2 kDa, observed by non-reducing SDS-PAGE.

    UniProt

    P08700

    Pathways

    JAK-STAT Signalweg, Regulation of Carbohydrate Metabolic Process, Autophagie
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