IL-10 Protein (AA 19-178)

Produktnummer ABIN2018048

Dieses Recombinant IL-10-Protein wird in CHO Cells exprimiert.

Kurzübersicht für IL-10 Protein (AA 19-178) (ABIN2018048)

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Ratte

Quelle: CHO Cells

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Produktdetails

Proteineigenschaft: AA 19-178

Produktmerkmale: ED50 <8 μg /mL, measured in a bioassay using C6 cells.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant rat Interleukin-10(IL-10) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Rat Interleukin-10 should be stable up to 1 week at 4°C or up to 2 months at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Andere Bezeichnung: Interleukin-10 (IL-10)

Hintergrund: Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80 % sequence homology with the Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays the ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory, however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Synonyms: B-TCGF, CSIF, TGIF

Molekulargewicht: 8-22 kDa, observed by reducing SDS-PAGE.

UniProt: P29456

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints