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IL-6 Receptor Protein (C-Term, Extracellular Domain)

Dieses Recombinant IL-6 Receptor-Protein wird in HEK-293T Cells produziert.
Produktnummer ABIN1684654

Kurzübersicht für IL-6 Receptor Protein (C-Term, Extracellular Domain) (ABIN1684654)

Target

Alle IL-6 Receptor (IL6R) Proteine anzeigen
IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Protein-Typ

Recombinant

Spezies

  • 16
  • 5
  • 4
Maus

Quelle

  • 10
  • 5
  • 5
  • 2
  • 1
  • 1
HEK-293T Cells

Reinheit

> 97 %, as determined by SDS-PAGE and HPLC
  • Proteineigenschaft

    C-Term, Extracellular Domain

    Spezifität

    Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.

    Produktmerkmale

    Recombinant mouse IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.

    Sterilität

    0.2 μm filtered

    Endotoxin-Niveau

    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS solution, pH7.2.

    Handhabung

    Avoid repeated freeze/thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.

    Haltbarkeit

    12-24 months
  • Target

    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

    Andere Bezeichnung

    CD126

    Hintergrund

    Neurotrophin-3 is found in neurons of the central nervous system. NT-3 is expressed also in muscles and its expression is down-regulated in denervated muscles. Many human gliomas express and secrete NT-3 into the conditioned medium.ome protein domains of NT-3 are identical with those of NGF and BDNF. NT-3 selectively supports the survival of neuronal cell populations. NT-3 has been shown recently to prevent death of cultured embryonic rat spinal motor neurons at picomolar concentrations. NT-3 has been shown to enhance sprouting of corticospinal tract during development and after adult spinal cord lesion. The activities of NT-3 and BDNF are additive in some systems. The biological activities of NT-3 are mediated by a receptor belonging to the trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 only binds weakly to the trk receptor which is a high-affinity receptor for NGF.

    UniProt

    P22272

    Pathways

    JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints
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