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IL36A/IL1F6 Protein

Recombinant IL36A/IL1F6-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN1344001

Kurzübersicht für IL36A/IL1F6 Protein (ABIN1344001)

Target

Alle IL36A/IL1F6 (IL1F6) Proteine anzeigen
IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 10
  • 7
Maus

Quelle

  • 14
  • 2
  • 1
Escherichia coli (E. coli)

Applikation

SDS-PAGE (SDS)

Reinheit

>95 % (SDS-PAGE)
  • Verwendungszweck

    IL-36alpha (aa 8-160) (mouse) (rec.) (untagged)

    Kreuzreaktivität

    Maus

    Produktmerkmale

    Mouse IL-36alpha (aa Arg8-His160) is untagged.

    Endotoxin-Niveau

    <0.01EU/μg purified protein (LAL test).

    Biological Activity Comment

    Induces secretion of IL-6 in BMDCs at a concentration of 100ng - 1μg/ml.
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  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstitute with 100 μL sterile water.

    Konzentration

    0.1 mg/mL

    Buffer

    Contains PBS.

    Handhabung

    After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

    Haltbarkeit

    6 months
  • Target

    IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

    Andere Bezeichnung

    IL-36alpha

    Hintergrund

    Interleukin-36alpha, Interleukin-1 Family Member 6, IL-1F6, FIL1epsilon, Interleukin-1epsilon, Interleukin-1 Homolog 1, IL-1H1

    IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported.

    Molekulargewicht

    ~17kDa

    UniProt

    Q9JLA2

    Pathways

    Cancer Immune Checkpoints
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