IL-11 Protein

Produktnummer ABIN1096894

Recombinant IL-11-Protein exprimiert in Yeast (Pichia pastoris).

Kurzübersicht für IL-11 Protein (ABIN1096894)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Yeast (Pichia pastoris)

Applikation: Functional Studies (Func)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human Interleukin-11/IL-11

Sequenz: GPPPGPPRVS PDPRAELDST VLLTRSLLAD TRQLAAQLRD KFPADGDHNL DSLPTLAMSA GALGALQLPG VLTRLRADLL SYLRHVQWLR RAGGSSLKTL EPELGTLQAR LDRLLRRLQL LMSRLALPQP PPDPPAPPLA PPSSAWGGIR AAHAILGGLH LTLDWAVRGL LLLKTRL

Produktmerkmale: Recombinant Human Interleukin-11/IL-11 is produced in P. pastoris by recombinant DNA technology. The protein has a molecular mass of approximately 19,0 kDa and is non-glycosylated. The protein is 177 amino acids in length and differs from the 178 amino acid length of native IL-11 by lacking the amino-terminal praline residue.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Kommentare:

Biological activity: ED50 is less than 0.2 ng/ml as determined by the dose-dependent stimulation of murine 7TD1 proliferation.Specific Activity of 8.0 x 106 IU/ mg.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 2 % Glycine, pH 7.2.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Andere Bezeichnung: il-11

Hintergrund: Interleukin 11 (IL-11) is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors.
Alternative Names: Interleukin-11, IL-11, Adipogenesis Inhibitory Factor, AGIF, Oprelvekin, IL11

Molekulargewicht: 19 kDa

UniProt: P20809

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion