IL-11 Protein (AA 22-199) (His tag)
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- Target Alle IL-11 (IL11) Proteine anzeigen
- IL-11 (IL11) (Interleukin 11 (IL11))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 22-199
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IL-11 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Human IL-11 Protein, His Tag
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL11 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Lagerung
- -20 °C
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- Target
- IL-11 (IL11) (Interleukin 11 (IL11))
- Andere Bezeichnung
- IL-11 (IL11 Produkte)
- Synonyme
- IL11 Protein, AGIF Protein, IL-11 Protein, Il-11 Protein, interleukin 11 Protein, IL11 Protein, Il11 Protein
- Hintergrund
- Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.
- Molekulargewicht
- 21.0 kDa
- NCBI Accession
- NP_000632
- Pathways
- JAK-STAT Signalweg, Negative Regulation of Hormone Secretion
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